ArticleThe Journal of experimental medicine1998
Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Bioengineering Interventions to Enhance the Capacity of the Gut Microbiota in Controlling Food Allergies.Life (Basel, Switzerland) · 2026Review
- Regulation of vascular permeability in anaphylaxis.British journal of pharmacology · 2018Review
- Mouse and human neutrophils induce anaphylaxis.The Journal of clinical investigation · 2011Article
- Neutrophils give us a shock.The Journal of clinical investigation · 2011Article
- Article
- Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils.Clinical and experimental immunology · 2008Article
- Acute immune and non-immune inflammatory response in spontaneously hypertensive rats and normotensive rats. Role of endogenous nitric oxide.Inflammation · 2007Article
- Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.Pharmacology & therapeutics · 2007Review
- Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.The Journal of experimental medicine · 2006Article
- Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction.The Journal of experimental medicine · 2003Article
- Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23.The Journal of clinical investigation · 2002Article
- Accumulation of platelets in the lung and liver and their degranulation following antigen-challenge in sensitized mice.British journal of pharmacology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells have long been believed to be the central effector cells in the development of immunoglobulin (Ig)E-dependent anaphylaxis. In this study, we investigated the role of mast cells in IgE-dependent hapten-induced active fatal anaphylaxis using mast cell-deficient WBB6F1- W/Wv (W/Wv) and congenic normal (+/+) mice. Although a 5-min delay in shock signs and death were observed in W/Wv mice, 100% fatal reactions to penicillin V (Pen V) occurred in both +/+ and W/Wv mice. Administration of monoclonal anti-IL-4 antibody completely prevented the fatal reactions, and the effect of anti-IL-4 was associated with its suppressive activity on Pen V-specific serum levels of IgE, but not IgG. The platelet-activating factor (PAF) antagonist, BN 50739, completely prevented the fatal reactions in both strains of mice. Our kinetic study revealed, in contrast to no elevation of plasma histamine level in W/Wv mice, high levels of PAF in the circulation after challenge in both +/+ and W/Wv mice, albeit to a lesser degree in the latter case. These data indicate that cells other than mast cells are sufficient to induce an IgE-dependent active fatal anaphylaxis by elaborating PAF, which is the critical mediator for fatal murine anaphylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.