ArticleMolecular biology of the cell1998
Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Gastric Cancer Harboring anOncoTargets and therapy · 2021Article
- Overexpression of NRG1 promotes progression of gastric cancer by regulating the self-renewal of cancer stem cells.Journal of gastroenterology · 2015Article
- GGF2 is neuroprotective in a rat model of cavernous nerve injury-induced erectile dysfunction.The journal of sexual medicine · 2015Article
- The ERBB3 receptor in cancer and cancer gene therapy.Cancer gene therapy · 2008Review
- HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion.Molecular biology of the cell · 2005Article
- Roles for neuregulins in human cancer.Clinical & experimental metastasis · 2004Review
- Article
- Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.Environmental health perspectives · 2000Review
- Molecular requirements for the effect of neuregulin on cell spreading, motility and colony organization.Oncogene · 2000Article
- ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases.The Journal of cell biology · 2000Article
- Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation.Oncogene · 1999Article
- Dynamics of adherence junctions during early stages of epithelial-mesenchymal transition: possible mechanisms of tube and alveolus formation in ontogeny.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuregulin, or neu differentiation factor, induces cell proliferation or differentiation through interaction with members of the ErbB family of receptor tyrosine kinases. We report that neuregulin can also induce profound morphogenic responses in cultured epithelial cells of different origins. These effects include scattering of small epithelial islands and rearrangement of larger cell islands into ordered ring-shaped arrays with internal lumens. The ring-forming cells are interconnected by cadherin- and beta-catenin-containing adherens junctions. In confluent cultures, neuregulin treatment induces formation of circular lumenlike gaps in the monolayer. Both cell scattering and ring formation are accompanied by a marked increase in cell motility that is independent of hepatocyte growth factor/scatter factor and its receptor (c-Met). Affinity-labeling experiments implied that a combination of ErbB-2 with ErbB-3 mediates the morphogenic signal of neuregulin in gastric cells. Indeed, a similar morphogenic effect could be reconstituted in nonresponsive cells by coexpression of ErbB-2 and -3. We conclude that a heterodimer between the kinase-defective neuregulin receptor, ErbB-3, and the coreceptor, ErbB-2, mediates the morphogenetic action of neuregulin.
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