ArticleMolecular biology of the cell1998
Direct involvement of N-cadherin-mediated signaling in muscle differentiation.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- Single-cell transcriptomics reveal mechanisms of skeletal muscle differentiation across duck embryonic development.Communications biology · 2026Article
- Fusion of Normoxic- and Hypoxic-Preconditioned Myoblasts Leads to Increased Hypertrophy.Cells · 2022Article
- Cdon promotes neural crest migration by regulating N-cadherin localization.Developmental biology · 2015Article
- Identification of differentially regulated secretome components during skeletal myogenesis.Molecular & cellular proteomics : MCP · 2011Article
- Engineering spatial control of multiple differentiation fates within a stem cell population.Biomaterials · 2011Article
- Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics.International journal of proteomics · 2011Article
- N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Normal myoblast fusion requires myoferlin.Development (Cambridge, England) · 2005Article
- p27Kip1 acts downstream of N-cadherin-mediated cell adhesion to promote myogenesis beyond cell cycle regulation.Molecular biology of the cell · 2005Article
- Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma.Oncogene · 2004Article
- Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses.Nucleic acids research · 2003Article
- Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.The Journal of cell biology · 2002Article
- Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton.The Journal of cell biology · 2002Article
- Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions.Molecular biology of the cell · 2000Article
- Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways.Molecular biology of the cell · 2000Article
- The effects of three-dimensional cell culture on single myoblasts.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-cell interactions, mediated by members of the cadherin family of Ca2+-dependent adhesion molecules, play key roles in morphogenetic processes as well as in the transduction of long-range growth and differentiation signals. In muscle differentiation cell adhesion is involved in both early stages of myogenic induction and in later stages of myoblast interaction and fusion. In this study we have explored the involvement of a specific cadherin, namely N-cadherin, in myogenic differentiation. For that purpose we have treated different established lines of cultured myoblasts with beads coated with N-cadherin-specific ligands, including a recombinant N-cadherin extracellular domain, and anti-N-cadherin antibodies. Immunofluorescent labeling for cadherins and catenins indicated that treatment with the cadherin-reactive beads for several hours enhances the assembly of cell-cell adherens-type junctions. Moreover, immunofluorescence and immunoblotting analyses indicated that treatment with the beads for 12-24 h induces myogenin expression and growth arrest, which are largely independent of cell plating density. Upon longer incubation with the beads (2-3 d) a major facilitation in the expression of several muscle-specific sarcomeric proteins and in cell fusion into myotubes was observed. These results suggest that surface clustering or immobilization of N-cadherin can directly trigger signaling events, which promote the activation of a myogenic differentiation program.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.