ArticleMolecular biology of the cell1998
Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Molecular biology of the cell · 2013Article
- Functional analysis of the Aspergillus nidulans kinome.PloS one · 2013Article
- Global analysis of serine-threonine protein kinase genes in Neurospora crassa.Eukaryotic cell · 2011Article
- Processive ubiquitin chain formation by the anaphase-promoting complex.Seminars in cell & developmental biology · 2011Review
- Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.The EMBO journal · 2011Article
- Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase.The Journal of cell biology · 2010Article
- Copy number suppressors of the Aspergillus nidulans nimA1 mitotic kinase display distinctive and highly dynamic cell cycle-regulated locations.Eukaryotic cell · 2008Article
- The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells.Eukaryotic cell · 2007Article
- Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.Molecular biology of the cell · 2006Article
- Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Eukaryotic cell · 2004Article
- TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest.Molecular biology of the cell · 2003Article
- Review
- Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB.The EMBO journal · 2002Article
- The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.The EMBO journal · 2002Article
- APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.The EMBO journal · 2001Article
- Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans.Molecular and cellular biology · 2001Article
- Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation.Genetics · 2000Article
- Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25Delta mutant cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Surprisingly, although highly temperature-sensitive, the bimA1(APC3) anaphase-promoting complex/cyclosome (APC/C) mutation does not cause arrest of mitotic exit. Instead, rapid inactivation of bimA1(APC3) is shown to promote repeating oscillations of chromosome condensation and decondensation, activation and inactivation of NIMA and p34(cdc2) kinases, and accumulation and degradation of NIMA, which all coordinately cycle multiple times without causing nuclear division. These bimA1(APC3)-induced cell cycle oscillations require active NIMA, because a nimA5 + bimA1(APC3) double mutant arrests in a mitotic state with very high p34(cdc2) H1 kinase activity. NIMA protein instability during S phase and G2 was also found to be controlled by the APC/C. The bimA1(APC3) mutation therefore first inactivates the APC/C but then allows its activation in a cyclic manner; these cycles depend on NIMA. We hypothesize that bimAAPC3 could be part of a cell cycle clock mechanism that is reset after inactivation of bimA1(APC3). The bimA1(APC3) mutation may also make the APC/C resistant to activation by mitotic substrates of the APC/C, such as cyclin B, Polo, and NIMA, causing mitotic delay. Once these regulators accumulate, they activate the APC/C, and cells exit from mitosis, which then allows this cycle to repeat. The data indicate that bimAAPC3 regulates the APC/C in a NIMA-dependent manner.
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