ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Long-lasting induction of astrocytic basic fibroblast growth factor by repeated injections of amphetamine: blockade by concurrent treatment with a glutamate antagonist.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 84 citations in OpenAlex.
- Review
- Inhibition of FGF Receptor-1 Suppresses Alcohol Consumption: Role of PI3 Kinase Signaling in Dorsomedial Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Escalated Oxycodone Self-Administration Causes Differential Striatal mRNA Expression of FGFs and IEGs Following Abstinence-Associated Incubation of Oxycodone Craving.Neuroscience · 2019Article
- bFGF expression is differentially regulated by cocaine seeking versus extinction in learning-related brain regions.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Fibroblast Growth Factor 2 in the Dorsomedial Striatum Is a Novel Positive Regulator of Alcohol Consumption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Region-specific effects of developmental exposure to cocaine on fibroblast growth factor-2 expression in the rat brain.Psychopharmacology · 2016Article
- Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Blocking Infralimbic Basic Fibroblast Growth Factor (bFGF or FGF2) Facilitates Extinction of Drug Seeking After Cocaine Self-Administration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Plasticity in the prefrontal cortex of adult rats.Frontiers in cellular neuroscience · 2015Review
- Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse.Neuroscience · 2014Review
- Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty.Neuropharmacology · 2014Review
- Evidence for fibroblast growth factor-2 as a mediator of amphetamine-enhanced motor improvement following stroke.PloS one · 2014Article
- Review
- Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances.Expert opinion on investigational drugs · 2012Review
- Long-term motor improvement after stroke is enhanced by short-term treatment with the alpha-2 antagonist, atipamezole.Brain research · 2010Article
- Article
- The Role of Glial Cells in Drug Abuse.Current drug abuse reviews · 2009Article
- Review. Psychological and neural mechanisms of relapse.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Stress and cocaine interact to modulate basic fibroblast growth factor (FGF-2) expression in rat brain.Psychopharmacology · 2008Article
- Regulation of netrin-1 receptors by amphetamine in the adult brain.Neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeated administration of stimulant drugs leads to lasting changes in their behavioral and neurochemical effects. These changes are initiated by drug actions in the somatodendritic regions of midbrain dopaminergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) and continue to develop for a period of time after termination of drug treatment. Here we show that repeated administration of amphetamine (3.0 mg/kg, i.p.; three injections, once every other day) results in sustained increases in basic fibroblast growth factor immunoreactivity (bFGF-IR) in both VTA and SNc, 200-500% over that seen in saline-treated animals. Increases were observed 24 hr, 72 hr, 1 week and 1 month after the last drug injection. Because glutamate participates in the development of sensitization to stimulant drugs, we assessed the effect of the glutamate antagonist, kynurenic acid (KYN), on amphetamine-induced bFGF-IR. Coadministration of KYN prevented the increases in bFGF-IR in both VTA and SNc assessed 1 week after the amphetamine treatment. No changes in bFGF-IR were observed in the nucleus accumbens or dorsal striatum. bFGF-IR was found to be associated with astrocytes and not with dopaminergic neurons. These findings suggest that sustained enhancement of astrocytic bFGF expression in DA somatodendritic regions is a mechanism whereby stimulant drugs exert enduring effects on midbrain DA function. We hypothesize that increased glutamatergic activity elicited by amphetamine and other stimulant drugs places excessive demands on the functioning of DA neurons recruiting regulatory and neuroprotective processes that lead to enduring changes in DA neuron functioning and connectivity.
Indexed as
Identifiers
9801391PMC6792884W2100870466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.