ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Schwann cells proliferate at rat neuromuscular junctions during development and regeneration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 86 citations in OpenAlex.
- The fate of the neuromuscular junction in peripheral nerve injury - current understanding and future research aims: A scoping review.JPRAS open · 2026Review
- Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling.JCI insight · 2026Article
- Origin, identity, and function of terminal Schwann cells.Trends in neurosciences · 2024Review
- Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions.Aging cell · 2023Article
- Peripheral glia diversity.Journal of anatomy · 2022Review
- Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells.Frontiers in pharmacology · 2022Article
- Preliminary Study of S100B and Sema3A Expression Patterns in Regenerating Muscle Implicates P75-Expressing Terminal Schwann Cells and Muscle Satellite Cells in Neuromuscular Junction Restoration.Frontiers in cell and developmental biology · 2022Article
- Terminal Schwann cells at the human neuromuscular junction.Brain communications · 2021Article
- Peripheral Nerve Regeneration and Muscle Reinnervation.International journal of molecular sciences · 2020Review
- Morphological remodeling during recovery of the neuromuscular junction from terminal Schwann cell ablation in adult mice.Scientific reports · 2020Article
- Specific labeling of synaptic schwann cells reveals unique cellular and molecular features.eLife · 2020Article
- More Than Mortar: Glia as Architects of Nervous System Development and Disease.Frontiers in cell and developmental biology · 2020Review
- Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1).PLoS genetics · 2019Article
- Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age-related morphological changes.Aging cell · 2018Article
- Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro.Scientific reports · 2018Article
- Clinical relevance of terminal Schwann cells: An overlooked component of the neuromuscular junction.Journal of neuroscience research · 2018Review
- Article
- Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury.BMC neuroscience · 2017Article
- Structural and Functional Abnormalities of the Neuromuscular Junction in the Trembler-J Homozygote Mouse Model of Congenital Hypomyelinating Neuropathy.Journal of neuropathology and experimental neurology · 2016Article
- Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease.Experimental neurology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terminal Schwann cells (TSCs) cover neuromuscular junctions and are important in the repair and maintenance of these synapses. We have examined how these cells are generated at developing junctions and how their number is regulated during repair of nerve injury. At birth, approximately half of the junctions in rat soleus and extensor digitorum longus muscles have one TSC soma. Somata are absent from the remainder, although Schwann cell (SC) processes arising from somata along the preterminal axon cover almost all of these synapses. By 2 months of age, junctions have gained an additional two to three TSCs. Most of this gain occurs during the first 2 postnatal weeks and largely precedes the expansion of endplate size. Although the initial addition is caused by cell migration, mitotic labeling shows extensive division of TSCs at junctions. A slower addition of TSCs occurs in adult muscles, and TSC number in the adult is correlated with endplate size. During repair of nerve injury, TSC number is regulated by a combination of signals from motor neurons and denervated tissue. As shown previously (Connor et al., 1987), denervation of adult muscles did not, in itself, cause TSC mitosis. However, TSCs became mitotic during reinnervation. Partial denervation induced division of TSCs at innervated but not denervated endplates. A disproportionate number of these mitotic cells were found at endplates contacted by TSC processes extended from nearby denervated endplates, contacts known to promote nerve sprouting. These results show an association between TSC mitotic activity and alterations in synaptic structure during development, sprouting, and reinnervation.
Indexed as
Identifiers
9801376PMC6792891W1828557676What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.