Evidence map›Paper›PMID 9801361›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998

Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors.

C A Del Negro, S H Chandler

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009
    Article
  9. Article
  10. Article
  11. Hypocretinergic control of spinal cord motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004
    Article
  12. Review
  13. Distinct subtypes of metabotropic glutamate receptors mediate differential actions on excitability of spinal respiratory motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C A Del NegroDepartment of Physiological Science, University of California at Los Angeles, Los Angeles, California 90095-1586, USA.
S H Chandler
University of California, Los Angeles · US

Funding

BRAIN STEM MECHANISMS CONTROLLING RHYTHMICAL JAW MOVEMENR01DE006193 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANDLER, SCOTT H · 1985 to 2007
$2.1M
NIDCR NIH HHS R01 DE006193NIDCR NIH HHS R01 DE-06193
6 · The paper itself

Abstract

We studied how metabotropic glutamate receptor (mGluR) activation modifies the synaptic and intrinsic membrane properties of neonatal rat trigeminal motoneurons using the broad-spectrum mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid [(1S,3R)-ACPD], group I/II antagonist (+/-)-alpha-methyl-4-carboxy-phenylglycine (MCPG), and group III agonist L-2-amino-4-phosphonobutanoate (L-AP4). (1S,3R)-ACPD depressed excitatory transmission to trigeminal motoneurons presynaptically and postsynaptically via presynaptic inhibition and by reducing the currents carried by ionotropic glutamate receptors selective for AMPA. (1S,3R)-ACPD also depolarized trigeminal motoneurons and increased input resistance by suppressing a Ba2+-sensitive leakage K+ current. These effects were not mimicked by L-AP4 (100-200 microM). High-threshold Ca2+ currents were also suppressed by (1S,3R)-ACPD. Repetitive stimulation of excitatory premotoneurons mimicked the postsynaptic effects of (1S, 3R)-ACPD. The postsynaptic effects of (1S,3R)-ACPD and repetitive stimulation were both antagonized by MCPG, suggesting that mGluRs were similarly activated in both experiments. We conclude that mGluRs can be recruited endogenously by glutamatergic premotoneurons and that mGluR-mediated depression of excitatory transmission, combined with increased postsynaptic excitability, enhances the signal-to-noise ratio of oral-related synaptic input to trigeminal motoneurons during rhythmical jaw movements.

Indexed as

6-Cyano-7-nitroquinoxaline-2,3-dionealpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBenzoatesCycloleucineExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGlycineMembrane PotentialsMotor NeuronsNeuroprotective AgentsN-MethylaspartatePatch-Clamp TechniquesRatsReceptors, Metabotropic Glutamate1-amino-1,3-dicarboxycyclopentane6-Cyano-7-nitroquinoxaline-2,3-dionealpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acidalpha-methyl-4-carboxyphenylglycineBenzoatesCycloleucineExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGlycineNeuroprotective AgentsN-MethylaspartateReceptors, Metabotropic GlutamateTetrodotoxin

Identifiers

PMID9801361
PMCPMC6792881
OpenAlexW2169832176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.