ArticleClinical and diagnostic laboratory immunology1998
Human T-cell lymphotropic virus type 1 tax among American blood donors.
Article in Clinical and diagnostic laboratory immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- First Description of Seronegative HTLV-1 Carriers in Argentina.The American journal of tropical medicine and hygiene · 2020Article
- Relative frequency of Human T-cell Lymphotropic Virus I/II in HIV/AIDS patients.Advanced biomedical research · 2014Article
- A comparative study of HIV-1 and HTLV-I protease structure and dynamics reveals a conserved residue interaction network.Journal of molecular modeling · 2011Article
- Can the level of immunosuppression in human immunodeficiency virus-infected patients affect the reliability of human T-cell lymphotropic virus type 2 serological diagnosis?Clinical and vaccine immunology : CVI · 2006Article
- Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2.Clinical and diagnostic laboratory immunology · 2003Article
- Unusually high incidence of positive HTLV I/II results among young female organ donors in the peripartum period.Digestive diseases and sciences · 2002Article
- Non-HIV retroviral associations with rheumatic disease.Current rheumatology reports · 2000Review
- Transmission of human T-cell lymphotropic virus type 1 tax to rabbits by tax-only-positive human cells.Clinical and diagnostic laboratory immunology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In the United States, all blood used for transfusion is tested for the presence of antibodies to the structural components of the human T-cell lymphotropic viruses types 1 and 2 (HTLV-1 and -2). Based on such serologic tests, the prevalence of HTLV-1 infection is estimated to range from 0.016 to 0.1%. As a consequence of studies of patients with mycosis fungoides and some of their healthy relatives who are antibody negative but were found to carry the tax sequence of HTLV-1 in their lymphocytes and who had antibodies to the p40(tax) protein, a study was undertaken to determine the prevalence of the "tax-only" state in 250 healthy blood donors and other volunteers. Using PCR and Southern analysis for cell lysates and using Western blotting for plasmas, 8.6% of the blood donors proved to be tax sequence positive and antibody positive. Sequence analysis of specimens from 22 individuals proved that 20 of the sequences were homologous with that of HTLV-1 while 2 resembled the HTLV-2 sequence. The latter were obtained from volunteers of Indian origin. The possible clinical significance of the tax-only carrier state is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.