ArticleThe EMBO journal1998
Positive autoregulation of the glial promoting factor glide/gcm.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Autoregulation of the glial gene reversed polarity in Drosophila.Scientific reports · 2025Article
- Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids.Nature communications · 2024Article
- Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons.Cell death discovery · 2023Article
- Article
- An evolutionary conserved interaction between the Gcm transcription factor and the SF1 nuclear receptor in the female reproductive system.Scientific reports · 2016Article
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- Enhanced Northern Blot detection of small RNA species in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2014Article
- Lineage specification in the fly nervous system and evolutionary implications.Cell cycle (Georgetown, Tex.) · 2013Review
- Polycomb controls gliogenesis by regulating the transient expression of the Gcm/Glide fate determinant.PLoS genetics · 2012Article
- Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Huckebein-mediated autoregulation of Glide/Gcm triggers glia specification.The EMBO journal · 2006Article
- Histone deacetylase 3 binds to and regulates the GCMa transcription factor.Nucleic acids research · 2006Article
- Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition.The EMBO journal · 2003Article
- Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis.Genetics · 2002Article
- Glide2, a second glial promoting factor in Drosophila melanogaster.The EMBO journal · 2001Article
- Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fly gliogenesis depends on the glial-cell-deficient/glial-cell-missing (glide/gcm) transcription factor. glide/gcm expression is necessary and sufficient to induce the glial fate within and outside the nervous system, indicating that the activity of this gene must be tightly regulated. The current model is that glide/gcm activates the glial fate by inducing the expression of glial-specific genes that are required to maintain such a fate. Previous observations on the null glide/gcmN7-4 allele evoked the possibility that another role of glide/gcm might be to maintain and/or amplify its own expression. Here we show that glide/gcm does positively autoregulate in vitro and in vivo, and that the glide/gcmN7-4 protein is not able to do so. We thereby provide the first direct evidence of both a target and a regulator of glide/gcm. Our data also demonstrate that glide/gcm transcription is regulated at two distinct steps: initiation, which is glide/gcm-independent, and maintenance, which requires glide/gcm. Interestingly, we have found that autoregulation requires the activity of additional cell-specific cofactors. The present results suggest transcriptional autoregulation is a mechanism for glial fate induction.
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