ArticleAmerican journal of human genetics1998
A comparative study of sibship tests of linkage and/or association.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Handling missing data in transmission disequilibrium test in nuclear families with one affected offspring.PloS one · 2012Article
- Haplotype association analyses in resources of mixed structure using Monte Carlo testing.BMC bioinformatics · 2010Article
- Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease.Neurogenetics · 2008Article
- Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study.Archives of otolaryngology--head & neck surgery · 2006Article
- PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size.BMC bioinformatics · 2006Article
- PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders.Genes and immunity · 2005Article
- Association testing in a linked region using large pedigrees.American journal of human genetics · 2005Article
- Accounting for linkage in family-based tests of association with missing parental genotypes.American journal of human genetics · 2003Article
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
- A test for linkage and association in general pedigrees: the pedigree disequilibrium test.American journal of human genetics · 2000Article
- Comparison of tests for association and linkage in incomplete families.American journal of human genetics · 2000Article
- Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus.American journal of human genetics · 2000Article
- A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission.American journal of human genetics · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Population-based tests of association have used data from either case-control studies or studies based on trios (affected child and parents). Case-control studies are more prone to false-positive results caused by inappropriate controls, which can occur if, for example, there is population admixture or stratification. An advantage of family-based tests is that cases and controls are well matched, but parental data may not always be available, especially for late-onset diseases. Three recent family-based tests of association and linkage utilize unaffected siblings as surrogates for untyped parents. In this paper, we propose an extension of one of these tests. We describe and compare the four tests in the context of a complex disease for both biallelic and multiallelic markers, as well as for sibships of different sizes. We also examine the consequences of having some parental data in the sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.