ArticleAmerican journal of human genetics1998
Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Pooled it
- Association of the ROBO1 gene with reading disabilities in a family-based analysis.Genes, brain, and behavior · 2014Article
- DCDC2 genetic variants and susceptibility to developmental dyslexia.Psychiatric genetics · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.Behavior genetics · 2011Review
- Linkage analysis of Tourette syndrome in a large Utah pedigree.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Genetics of developmental dyslexia.European child & adolescent psychiatry · 2010Review
- Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses.Human genetics · 2004Article
- Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effects.Molecular psychiatry · 2004Article
- A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.Molecular psychiatry · 2003Article
- Evidence for linkage and association with reading disability on 6p21.3-22.American journal of human genetics · 2002Article
- Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span.American journal of human genetics · 2000Article
- Chromosome 6p influences on different dyslexia-related cognitive processes: further confirmation.American journal of human genetics · 2000Article
- Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses.American journal of human genetics · 2000Article
- A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics.American journal of human genetics · 1999Article
- A new gene (DYX3) for dyslexia is located on chromosome 2.Journal of medical genetics · 1999Article
- Reading and spelling disorders: clinical features and causes.European child & adolescent psychiatry · 1999Review
- A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia.American journal of human genetics · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have suggested that a locus predisposing to specific reading disability (dyslexia) resides on chromosome 6p23-p21.3. We investigated 79 families having at least two siblings affected with phonological coding dyslexia, the most common form of reading disability (617 people genotyped, 294 affected), and we tested for linkage with the genetic markers reported to be linked to dyslexia in those studies. No evidence for linkage was found by LOD score analysis or affected-sib-pair methods. However, using the affected-pedigree-member (APM) method, we detected significant evidence for linkage and/or association with some markers when we used published allele frequencies with weighting of rarer alleles. APM results were not significant when we used marker allele frequencies estimated from parents. Furthermore, results were not significant with the more robust SIMIBD method using either published or parental marker frequencies. Finally, family-based association analysis using the AFBAC program showed no evidence for association with any marker. We conclude that the APM method should be used only with extreme caution, because it appears to have generated false-positive results. In summary, using a large data set with high power to detect linkage, we were unable to find evidence for linkage or association between phonological coding dyslexia and chromosome 6p markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.