ArticleAmerican journal of human genetics1998
Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.Nature genetics · 2017Article
- Dominant Transmission Observed in Adolescents and Families With Orthostatic Intolerance.Pediatric neurology · 2017Article
- The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population.Journal of human hypertension · 2015Article
- The association of an adenine insertion variant in the 5'UTR of the endothelin-1 gene with hypertension and orthostatic hypotension.Archives of medical science : AMS · 2012Article
- The SLC14 gene family of urea transporters.Pflugers Archiv : European journal of physiology · 2004Review
- Trapping and sequence analysis of 1138 putative exons from human chromosome 18.Molecular psychiatry · 2003Article
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Authors and funding
12 authors.
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Abstract
Familial orthostatic hypotensive disorder is characterized by light-headedness on standing, which may worsen to syncope, palpitations, and blue-purple ankle discoloration, and is accompanied by a marked decrease in systolic blood pressure, an increase in diastolic pressure, and tachycardia, all of which resolve when supine. We ascertained three families in which this disorder is inherited as an autosomal dominant trait with reduced penetrance. A genomewide scan was conducted in the two largest families, and three regions with multipoint LOD scores >1.5 were identified. Follow-up of these regions with additional markers in all three families yielded significant evidence of linkage at chromosome 18q. A maximum multipoint LOD score of 3.21 in the three families was observed at D18S1367, although the smallest family had negative LOD scores in the entire region. There was significant evidence of linkage in the presence of heterogeneity at 18q, with a maximum LOD score of 3.92 at D18S1367 in the two linked families. Identification of the gene responsible for orthostatic hypotensive disorder in these families may advance understanding of the general regulatory pathways involved in the continuum, from hypotension to hypertension, of blood pressure.
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