ArticleBritish journal of cancer1998
Comparison of benign and malignant follicular thyroid tumours by comparative genomic hybridization.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma.Oncotarget · 2016Article
- DNA copy number variations characterize benign and malignant thyroid tumors.The Journal of clinical endocrinology and metabolism · 2013Article
- Genomic differences in benign and malignant follicular thyroid tumours using 1-Mb array-comparative genomic hybridisation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization.Endocrine pathology · 2011Article
- Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis.Clinical chemistry · 2010Article
- Genetic and biological subgroups of low-stage follicular thyroid cancer.The American journal of pathology · 2003Article
- Follicular, papillary, and "hybrid" carcinomas of the thyroid.Endocrine pathology · 2002Review
- Deletion of 11q23 and cyclin D1 overexpression are frequent aberrations in parathyroid adenomas.The American journal of pathology · 2001Article
- Mechanisms underlying losses of heterozygosity in human colorectal cancers.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- DNA copy number changes in thyroid carcinoma.The American journal of pathology · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA copy number changes were compared in 29 histologically benign follicular adenomas, of which five were atypical, and 13 follicular carcinomas of the thyroid by comparative genomic hybridization. DNA copy number changes were frequent in adenomas (14 out of 29, 48%). Most changes were gains, and they always involved a gain of the entire chromosome 7 (10 out of 29, 34%); other common gains involved chromosomes 5 (28%), 9 (10%), 12 (24%), 14 (21%), 17 (17%), 18 (14%) and X (17%). Losses were found only in four (14%) adenomas. Two of the five atypical adenomas had DNA copy number losses, and none had gains. Unlike adenomas, gains were rare and losses were frequent in carcinomas. A loss of chromosome 22 or 22q was particularly common in carcinomas (6 out of 13, 46%), whereas a loss of chromosome 22 was found in only two (7%) adenomas, one of which was atypical (P = 0.002). A loss of 1p was also frequent in carcinomas (31%), but gains of chromosomes 5, 7, 12, 14 or X that were common in adenomas were not found. Loss of chromosome 22 or 22q was present in six of the eight widely invasive follicular carcinomas, but in only one of the five minimally invasive carcinomas. We conclude that large DNA copy number changes are common in thyroid adenomas. These changes are strikingly different from those found in follicular carcinomas consisting of few losses and frequent gains, especially those of chromosome 7. A loss of chromosome 22 is common in widely invasive follicular carcinoma.
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