ArticleThe American journal of physiology1998
M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder.
Article in The American journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 122 citations in OpenAlex.
- The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial.International urogynecology journal · 2018Trial
- Design, synthesis and in vitro evaluation of a Dopa-organoboron compound that acts as a bladder relaxant through non-catecholamine receptors.Molecular diversity · 2019Article
- Pharmacological methods for the preclinical assessment of therapeutics for OAB: an up-to-date review.International urogynecology journal · 2016Review
- Progressive changes in detrusor function and micturition patterns with chronic bladder ischemia.Investigative and clinical urology · 2016Article
- Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis.Age (Dordrecht, Netherlands) · 2016Article
- Medical management of neurogenic bladder with oral therapy.Translational andrology and urology · 2016Review
- Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms.BMC urology · 2015Article
- Alterations of heart rate variability in women with overactive bladder syndrome.International urogynecology journal · 2012Article
- Article
- A review and additional post-hoc analyses of the incidence and impact of constipation observed in darifenacin clinical trials.Drug, healthcare and patient safety · 2012Article
- The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.The Journal of pharmacology and experimental therapeutics · 2010Article
- Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Perspectives on overactive bladder in the elderly population.World journal of urology · 2009Review
- Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle.The Journal of pharmacology and experimental therapeutics · 2009Article
- Clinical pharmacokinetics and pharmacodynamics of solifenacin.Clinical pharmacokinetics · 2009Review
- Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.World journal of urology · 2008Article
- Does anticholinergic medication have a role in treating men with overactive bladder and benign prostatic hyperplasia?Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- A review of solifenacin in the treatment of urinary incontinence.Therapeutics and clinical risk management · 2008Article
- Overactive bladder: pharmacologic treatments in the neurogenic population.Reviews in urology · 2008Article
- [Oral anticholinergics in overactive bladder].Der Urologe. Ausg. A · 2006Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats that had their major pelvic ganglion bilaterally removed. Denervation induced both hypertrophy and a supersensitivity of the bladders to agonist. The affinities in control bladders for antagonism of carbachol-induced contractions were consistent with M3-mediated contractions. Affinities in denervated bladders for 4-diphenlacetoxy-N-methylpiperidine methiodide (8.5) and p-fluoro hexahydrosilodifenidol (6.6) were consistent with M2-mediated contractions, although the methoctramine affinity (6.5) was consistent with M3-mediated contractions. Subtype-selective immunoprecipitation of muscarinic receptors revealed a 50% increase in total and a 60% increase in M2 receptor density with no change in M3 receptor density in denervated bladders compared with normal or sham-operated controls. This increase in M2 receptor density is consistent with the change in affinity of the antagonists for inhibition of carbachol-induced contractions and may indicate that M2 receptors or a combination of M2 and M3 receptors directly mediates smooth muscle contraction in the denervated bladder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.