ArticleProceedings of the National Academy of Sciences of the United States of America1998
Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 213 citations in OpenAlex.
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- The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.Neural plasticity · 2018Review
- What is CAR doing in the middle of the adult neurogenic road?Neurogenesis (Austin, Tex.) · 2017Article
- SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus.Frontiers in molecular neuroscience · 2017Article
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- Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp.Cell reports · 2015Article
- Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM).Bioarchitecture · 2015Review
- Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.Frontiers in cellular neuroscience · 2015Review
- Activity dependent CAM cleavage and neurotransmission.Frontiers in cellular neuroscience · 2015Review
- NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations.Journal of molecular neuroscience : MN · 2014Article
- Distinctive PSA-NCAM and NCAM hallmarks in glutamate-induced dendritic atrophy and synaptic disassembly.PloS one · 2014Article
- Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.The Journal of biological chemistry · 2013Article
- Polysialylated NCAM and ephrinA/EphA regulate synaptic development of GABAergic interneurons in prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats.Age (Dordrecht, Netherlands) · 2012Article
- Building and remodeling synapses.Hippocampus · 2012Article
- Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting.Cellular and molecular life sciences : CMLS · 2012Article
1 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
Cell adhesion molecules (CAMs) are known to be involved in a variety of developmental processes that play key roles in the establishment of synaptic connectivity during embryonic development, but recent evidence implicates the same molecules in synaptic plasticity of the adult. In the present study, we have used neural CAM (NCAM)-deficient mice, which have learning and behavioral deficits, to evaluate NCAM function in the hippocampal mossy fiber system. Morphological studies demonstrated that fasciculation and laminar growth of mossy fibers were strongly affected, leading to innervation of CA3 pyramidal cells at ectopic sites, whereas individual mossy fiber boutons appeared normal. Electrophysiological recordings performed in hippocampal slice preparations revealed that both basal synaptic transmission and two forms of short-term plasticity, i.e., paired-pulse facilitation and frequency facilitation, were normal in mice lacking all forms of NCAM. However, long-term potentiation of glutamatergic excitatory synapses after brief trains of repetitive stimulation was abolished. Taken together, these results strongly suggest that in the hippocampal mossy fiber system, NCAM is essential both for correct axonal growth and synaptogenesis and for long-term changes in synaptic strength.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.