ArticleProceedings of the National Academy of Sciences of the United States of America1998
p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 139 citations in OpenAlex.
- SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation.Cell death & disease · 2025Article
- Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer.World journal of gastrointestinal oncology · 2023Review
- CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.Cancer discovery · 2018Article
- Nucleolar Stress: hallmarks, sensing mechanism and diseases.Cell stress · 2018Review
- Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice.Experimental and therapeutic medicine · 2017Article
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- P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway.Cancer research · 2014Article
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- NMI mediates transcription-independent ARF regulation in response to cellular stresses.Molecular biology of the cell · 2012Article
- p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.The Journal of biological chemistry · 2012Article
- P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.The Journal of clinical investigation · 2012Article
- Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.Molecular and cellular biology · 2012Article
- SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.Journal of virology · 2011Article
- Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis.Leukemia · 2011Article
- Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment.Molecular and cellular biology · 2011Article
- Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.Oncogene · 2008Article
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- Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.Journal of virology · 2008Article
- Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV.Journal of virology · 2008Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
The Ink4a/Arf locus encodes p16(Ink4a) and p19(Arf) and is among the most frequently mutated tumor suppressor loci in human cancer. In mice, many of these effects appear to be mediated by interactions between p19(Arf) and the p53 tumor-suppressor protein. Because Tp53 mutations are a common feature of the multistep pre-B cell transformation process mediated by Abelson murine leukemia virus (Ab-MLV), we examined the possibility that proteins encoded by the Ink4a/Arf locus also play a role in Abelson virus transformation. Analyses of primary transformants revealed that both p16(Ink4a) and p19(Arf) are expressed in many of the cells as they emerge from the apoptotic crisis that characterizes the transformation process. Analyses of primary transformants from Ink4a/Arf null mice revealed that these cells bypassed crisis. Because expression of p19(Arf) but not p16 (Ink4a) induced apoptosis in Ab-MLV-transformed pre-B cells, p19(Arf) appears to be responsible for these events. Consistent with the link between p19(Arf) and p53, Ink4a/Arf expression correlates with or precedes the emergence of cells expressing mutant p53. These data demonstrate that p19(Arf) is an important part of the cellular defense mounted against transforming signals from the Abl oncoprotein and provide direct evidence that the p19(Arf)-p53 regulatory loop plays an important role in lymphoma induction.
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