ArticleProceedings of the National Academy of Sciences of the United States of America1998
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells.Nature communications · 2020Article
- Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.The Journal of clinical investigation · 2019Article
- The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments.Current osteoporosis reports · 2017Review
- An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution.Frontiers in immunology · 2017Article
- Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.Immunity · 2016Article
- The B-cell receptor orchestrates environment-mediated lymphoma survival and drug resistance in B-cell malignancies.Oncogene · 2014Review
- B-lymphocyte tolerance and effector function in immunity and autoimmunity.Immunologic research · 2013Review
- Cre-mediated targeted gene activation in the middle silk glands of transgenic silkworms (Bombyx mori).Transgenic research · 2013Article
- Beyond transitional selection: New roles for BLyS in peripheral tolerance.Drug development research · 2011Article
- Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.The Journal of experimental medicine · 2011Article
- GI GEMs: genetically engineered mouse models of gastrointestinal disease.Gastroenterology · 2011Review
- A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Adopting the good reFLEXes when generating conditional alterations in the mouse genome.Transgenic research · 2007Review
- Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Early preplasma cells define a tolerance checkpoint for autoreactive B cells.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Human autoantibody silencing by immunoglobulin light chains.The Journal of experimental medicine · 2004Article
- Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.Molecular and cellular biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing autoreactive B cells edit their B cell antigen receptor (BCR) in the bone marrow and are clonally deleted when they fail to reexpress an innocent BCR. Here, inducible Cre-loxP-mediated gene inversion is used to change the specificity of the BCR on mature IgM+ IgD+ B cells in vivo to address the fate of lymphocytes encountering self-antigens at this developmental stage. Expression of an autoreactive BCR on mature B cells leads to their rapid elimination from the periphery, a process that is inhibited by constitutive bcl-2 transgene expression in an antigen dose-dependent manner. Thus, selection of mature B cells into the long-lived peripheral pool does not prevent their deletion upon encounter of self-antigens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.