ArticleProceedings of the National Academy of Sciences of the United States of America1998
A conventional myosin motor drives neurite outgrowth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 102 citations in OpenAlex.
- Role of olfactory receptor Olfr544 in neuronal cells: Insights into neurite outgrowth and CREB signaling.iScience · 2026Article
- The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.Cell proliferation · 2021Article
- Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment.Cells · 2020Review
- Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.Journal of proteomics · 2018Article
- Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis.Frontiers in molecular neuroscience · 2017Article
- Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization.International journal of biological sciences · 2016Article
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Frontiers in cellular neuroscience · 2016Review
- Non-muscle myosin II in disease: mechanisms and therapeutic opportunities.Disease models & mechanisms · 2015Review
- The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis.The Journal of biological chemistry · 2013Article
- Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans.Journal of neurochemistry · 2012Article
- Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.Laboratory investigation; a journal of technical methods and pathology · 2011Article
- Unconventional processive mechanics of non-muscle myosin IIB.The Journal of biological chemistry · 2010Article
- Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Conventional myosins - unconventional functions.Biophysical reviews · 2010Review
- Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading.PloS one · 2010Article
- Myosin II tailpiece determines its paracrystal structure, filament assembly properties, and cellular localization.The Journal of biological chemistry · 2009Article
- Dorsal root ganglion neurons react to semaphorin 3A application through a biphasic response that requires multiple myosin II isoforms.Molecular biology of the cell · 2009Article
- Myosin IIC: a third molecular motor driving neuronal dynamics.Molecular biology of the cell · 2008Article
- Coordination of actin filament and microtubule dynamics during neurite outgrowth.Developmental cell · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neuritic outgrowth is a striking example of directed motility, powered through the actions of molecular motors. Members of the myosin superfamily of actin-associated motors have been implicated in this complex process. Although conventional myosin II is known to be present in neurons, where it is localized at the leading edge of growth cones and in the cell cortex close to the plasma membrane, its functional involvement in growth cone motility has remained unproven. Here, we show that antisense oligodeoxyribonucleotides, complementary to a specific isoform of conventional myosin (myosin IIB), attenuate filopodial extension whereas sense and scrambled control oligodeoxyribonucleotides have no effect. Attenuation is shown to be reversible, neurite outgrowth being restored after cessation of the antisense regimen. Myosin IIB mRNA was present during active neurite extension, but levels were minimal in phenotypically rounded cells before neurite outgrowth and message levels decreased during antisense treatment. By contrast, the myosin IIA isoform is shown to be expressed constitutively both before and during neurite outgrowth and throughout exposure to myosin IIB antisense oligodeoxyribonucleotides. These results provide direct evidence that a conventional two-headed myosin is required for growth cone motility and is responsible, at least in part, for driving neuritic process outgrowth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.