ArticleProceedings of the National Academy of Sciences of the United States of America1998
Lactone-ring-cleaving enzyme: genetic analysis, novel RNA editing, and evolutionary implications.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Immobilizing D-lactonohydrolase with 3D-printed hollow filaments to improve the enzyme stability and reusability.Biotechnology letters · 2025Article
- Review
- Industrial kinetic resolution of d,l-pantolactone by an immobilized whole-cell biocatalyst.RSC advances · 2021Article
- The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.International journal of molecular sciences · 2021Review
- The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients.Frontiers in cardiovascular medicine · 2021Article
- Biocatalytic kinetic resolution of d,l-pantolactone by using a novel recombinant d-lactonase.RSC advances · 2020Article
- Alzheimer's Disease and Paraoxonase 1 (The open biochemistry journal · 2017Article
- Virulence Factors as Targets for Anticryptococcal Therapy.Journal of fungi (Basel, Switzerland) · 2016Review
- Biodegradation of Mycotoxins: Tales from Known and Unexplored Worlds.Frontiers in microbiology · 2016Review
- Benzoxazinoids in rye allelopathy - from discovery to application in sustainable weed control and organic farming.Journal of chemical ecology · 2013Review
- The human paraoxonase gene cluster as a target in the treatment of atherosclerosis.Antioxidants & redox signaling · 2012Review
- Article
- dbRES: a web-oriented database for annotated RNA editing sites.Nucleic acids research · 2007Article
- Cloning and characterization of gluconolactone oxidase of Penicillium cyaneo-fulvum ATCC 10431 and evaluation of its use for production of D-erythorbic acid in recombinant Pichia pastoris.Applied and environmental microbiology · 2004Article
- Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1.Applied and environmental microbiology · 2003Article
- Arthrobacter strain VAI-A utilizes acyl-homoserine lactone inactivation products and stimulates quorum signal biodegradation by Variovorax paradoxus.Applied and environmental microbiology · 2003Article
- Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus.Journal of bacteriology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A lactonohydrolase from Fusarium oxysporum AKU 3702 is an enzyme catalyzing the hydrolysis of aldonate lactones to the corresponding aldonic acids. The amino acid sequences of the NH2 terminus and internal peptide fragments of the enzyme were determined to prepare synthetic oligonucleotides as primers for the PCR. An approximate 1, 000-base genomic DNA fragment thus amplified was used as the probe to clone both genomic DNA and cDNA for the enzyme. The lactonohydrolase genomic gene consists of six exons separated by five short introns. A novel type of RNA editing, in which lactonohydrolase mRNA included the insertion of guanosine and cytidine residues, was observed. The predicted amino acid sequence of the cloned lactonohydrolase cDNA showed significant similarity to those of the gluconolactonase from Zymomonas mobilis, and paraoxonases from human and rabbit, forming a unique superfamily consisting of C-O cleaving enzymes and P-O cleaving enzymes. Lactonohydrolase was expressed under the control of the lac promoter in Escherichia coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.