ArticleThe Journal of clinical investigation1998
Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers.Frontiers in endocrinology · 2021Review
- Type 1 diabetes in a Nigerian family - occurrence in three out of four siblings: A case report.World journal of diabetes · 2019Article
- Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.Current diabetes reports · 2016Review
- Chromosome region 2p25 is linked and associated with type 1 diabetes in Colombia.Journal of genetics · 2010Article
- Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity.Genes and immunity · 2007Article
- Celiac disease and HLA in a Bedouin kindred.Human immunology · 2006Article
- Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.Genes and immunity · 2002Article
- Genetics of type 1 diabetes mellitus.Genes and immunity · 2002Review
- A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.American journal of human genetics · 2001Article
- Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.American journal of human genetics · 2001Article
- Age and sex based genetic locus heterogeneity in type 1 diabetes.Journal of medical genetics · 2000Article
- Multiple genes/multiple autoantigens role in type 1 diabetes.Clinical reviews in allergy & immunology · 2000Review
- Article
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Authors and funding
10 authors.
Funding
Abstract
Based on a genomic search for linkage, a locus contributing to type 1 diabetes in a large Bedouin Arab family (19 affected relatives) maps to the long arm of chromosome 10 (10q25; nonparametric linkage = 4.99; P = 0.00004). All affected relatives carry one or two high-risk HLA-DR3 haplotypes that are rarely found in other family members. One chromosome 10 haplotype, the B haplotype, was transmitted from a heterozygous parent to 13 of 13 affected offspring compared to 10 of 23 unaffected siblings. Recombination events occurring on this haplotype place the susceptibility locus in an 8-cM interval between markers D10S1750 and D10S1773. Two adjacent markers, D10S592 and D10S554, showed evidence of linkage disequilibrium with the disease locus. A 273-bp allele at D10S592 was transmitted to 8 of 10 affected offspring compared to 3 of 14 unaffected siblings, and a 151-bp allele at D10S554 was transmitted to 15 of 15 affected offspring compared with 10 of 24 unaffected siblings. D10S554 and D10S592 and the closest flanking markers are contained in a 1,240-kb yeast artificial chromosome, a region small enough to proceed with positional cloning.
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