ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Expression of ciliary tektins in brain and sensory development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
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- miR-199-5p regulates spermiogenesis at the posttranscriptional level via targeting Tekt1 in allotriploid crucian carp.Journal of animal science and biotechnology · 2022Article
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- Downregulation of KIF2C and TEKT2 is associated with male infertility and testicular carcinoma.Aging · 2021Article
- RNAi-Mediated Knockdown ofInsects · 2019Article
- Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis.Scientific reports · 2018Article
- Association of polymorphisms in tektin-t gene with idiopathic asthenozoospermia in Sichuan, China.Journal of assisted reproduction and genetics · 2016Article
- The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility.Journal of assisted reproduction and genetics · 2016Review
- Insights into the structure and function of ciliary and flagellar doublet microtubules: tektins, Ca2+-binding proteins, and stable protofilaments.The Journal of biological chemistry · 2014Article
- Molecular cloning and subcellular localization of Tektin2-binding protein 1 (Ccdc 172) in rat spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Axonemal positioning and orientation in three-dimensional space for primary cilia: what is known, what is assumed, and what needs clarification.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Tektin 3 is required for progressive sperm motility in mice.Molecular reproduction and development · 2009Article
- Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis.The Journal of cell biology · 2008Article
- The tektin family of microtubule-stabilizing proteins.Genome biology · 2008Review
- Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.Molecular and cellular biology · 2004Article
- The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes.Genome research · 2001Article
- The Rib43a protein is associated with forming the specialized protofilament ribbons of flagellar microtubules in Chlamydomonas.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Many types of neural tissues and sensory cells possess either motile or primary cilia. We report the first mammalian (murine testis) cDNA for tektin, a protein unique to cilia, flagella, and centrioles, which we have used to identify related proteins and genes in sensory tissues. Comparison with the sequence database reveals that tektins are a gene family, spanning evolution from Caenorhabditis elegans (in which they correlate with touch receptor cilia) and Drosophila melanogaster, to Mus musculus and Homo sapiens (in which they are found in brain, retina, melanocytes, and at least 13 other tissues). The peptide sequence RPNVELCRD, or a variant of it, is a prominent feature of tektins and is likely to form a functionally important protein domain. Using the cDNA as a probe, we determined the onset, relative levels, and locations of tektin expression in mouse for several adult tissues and embryonic stages by Northern blot analysis and in situ hybridization. Tektin expression is significant in adult brain and in the choroid plexus, the forming retina (primitive ependymal zone corresponding to early differentiating photoreceptor cells), and olfactory receptor neurons of stage embryonic day 14 embryos. There is a striking correlation of tektin expression with the known presence of either motile or primary cilia. The evolutionary conservation of tektins and their association with tubulin in cilia and centriole formation make them important and useful molecular targets for the study of neural development.
Indexed as
Identifiers
9786996PMC6793524W2171210309What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.