ArticleSurgery today1998
Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma.
Article in Surgery today, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer.Hereditas · 2022Article
- Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes.Pathology oncology research : POR · 2021Article
- Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system.Breast cancer research : BCR · 2020Article
- MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer.Molecular medicine reports · 2020Article
- Review
- Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.Biological procedures online · 2018Article
- CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression.Oncotarget · 2017Article
- Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines.PloS one · 2015Article
- Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3.Journal of proteome research · 2014Article
- Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.Molecular & cellular proteomics : MCP · 2014Article
- Biomarkers for predicting future metastasis of human gastrointestinal tumors.Cellular and molecular life sciences : CMLS · 2013Review
- ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.World journal of gastroenterology · 2013Article
- Association between ITGA2 C807T polymorphism and gastric cancer risk.World journal of gastroenterology · 2011Article
- Article
- Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.Clinical & experimental metastasis · 2010Article
- Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets.Expert reviews in molecular medicine · 2010Review
- Revisiting the seed and soil in cancer metastasis.The international journal of biochemistry & cell biology · 2009Review
- Regional administration of oncolytic Echovirus 1 as a novel therapy for the peritoneal dissemination of gastric cancer.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected].Neoplasia (New York, N.Y.) · 2008Article
- Identification of oligopeptides binding to peritoneal tumors of gastric cancer.Cancer science · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of alpha2beta1 and alpha3beta1 integrins was studied immunohistochemically in 110 resected human gastric carcinomas. Formalin-fixed and paraffin-embedded samples were serially sectioned and stained with monoclonal antibodies specifically against the alpha2 and alpha3 subunits of beta1 integrins. Approximately 27% of the tumors expressed alpha2beta1 integrin, and 20% expressed alpha3beta1 integrin. The expression of alpha2beta1 integrin was associated with lymph node and liver metastases (P < 0.05 and P < 0.05, respectively), and the expression of alpha3beta1 integrin was associated with liver and peritoneal metastases (P < 0.005 and P < 0.0005, respectively). A multivariate analysis by the logistic regression model revealed that the expression of alpha2beta1 and/or alpha3beta1 integrins was an independent factor related to liver metastasis, and that the expression of alpha3beta1 integrin was as strong an influence on the formation of peritoneal metastases as the depth of invasion. The expression of alpha3beta1 integrin also correlated with increased invasiveness of the tumor; however, there was no correlation between alpha2beta1 integrin expression and the invasiveness. These results suggest that alpha2beta1 and alpha3beta1 integrins have separate influences on the metastatic properties of cancer cells.
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Registered trials
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