ArticleInfection and immunity1998
Morphological transition of Paracoccidioides brasiliensis conidia to yeast cells: in vivo inhibition in females.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Polymorphism in the Promoter Region of theFrontiers in immunology · 2020Trial
- Allocation of resources among multiple daughter cells.The Journal of cell biology · 2025Article
- Allocation of resources among multiple daughter cells.bioRxiv : the preprint server for biology · 2025Article
- Common virulence factors betweenCurrent research in microbial sciences · 2024Review
- A Case-Control Study of Paracoccidioidomycosis in Women: The Hormonal Protection Revisited.Journal of fungi (Basel, Switzerland) · 2021Article
- Paracoccidioimycosis and white individuals: Susceptibility and biogeographic aspects in an important endemic area in Brazil.PLoS neglected tropical diseases · 2021Article
- Living Within the Macrophage: Dimorphic Fungal Pathogen Intracellular Metabolism.Frontiers in cellular and infection microbiology · 2020Review
- Serological Evidence of Infection by Paracoccidioides brasiliensis in Dogs with Leishmaniasis.Mycopathologia · 2017Article
- Paracoccidioidomycosis: Current Perspectives from Brazil.The open microbiology journal · 2017Review
- Review
- Decreased expression of 14-3-3 in Paracoccidioides brasiliensis confirms its involvement in fungal pathogenesis.Virulence · 2016Article
- Paracoccidioides-host Interaction: An Overview on Recent Advances in the Paracoccidioidomycosis.Frontiers in microbiology · 2015Review
- Hormones and the resistance of women to paracoccidioidomycosis.Clinical microbiology reviews · 2011Review
- Influence of 17β-estradiol on gene expression of Paracoccidioides during mycelia-to-yeast transition.PloS one · 2011Article
- Immunological basis for the gender differences in murine Paracoccidioides brasiliensis infection.PloS one · 2010Article
- Epidemiological profile of cryptococcal meningitis patients in Rio Grande do Sul, Brazil.Mycopathologia · 2008Article
- Chronic paracoccidioidomycosis in a female patient in Austria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Article
- Paracoccidioidomycosis in a woman with idiopathic hirsutism.Mycopathologia · 2004Article
- Asymptomatic presentation of chronic pulmonary paracoccidioidomycosis: case report and review.Mycopathologia · 2004Review
- Paracoccidioides brasiliensis 87-kilodalton antigen, a heat shock protein useful in diagnosis: characterization, purification, and detection in biopsy material via immunohistochemistry.Journal of clinical microbiology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical paracoccidioidomycosis is 13 times more common in men than in women. Estrogen inhibits the transition of mycelia or conidia (the saprophytic form of Paracoccidioides brasiliensis) to yeasts (the parasitic form) in vitro. Here, we show that, in male mice that were infected intranasally (mimicking natural infection) the transition of conidia in bronchoalveolar lavage fluids to intermediate forms and yeasts occurred over 24 to 96 h; CFU and yeasts (shown by histopathology) increased subsequently. In females, transition did not occur and infection cleared. These events in vivo are consistent with epidemiological and in vitro observations, suggesting that female hormones block transition and are responsible for resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.