ArticleInfection and immunity1998
Protection by CD4 or CD8 T cells against pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Cytotoxic granules and effector molecules from immune cells in tuberculosis: Mechanisms of host defense and therapeutic potential.Virulence · 2025Review
- Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function.Cellular & molecular biology letters · 2024Article
- Urban Air Pollution Particulates Suppress Human T-Cell Responses toInternational journal of environmental research and public health · 2019Article
- Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8Mucosal immunology · 2018Article
- Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection.Scientific reports · 2013Article
- CD8+ T cells and risk for bacterial pneumonia and all-cause mortality among HIV-infected women.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells.Mucosal immunology · 2011Article
- CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.Cancer cell · 2010Article
- Mechanisms of T-lymphocyte accumulation during experimental pleural infection induced by Mycobacterium bovis BCG.Infection and immunity · 2008Article
- Age-related waning of in vitro Interferon-gamma levels against r32kDaBCG in BCG vaccinated children.Journal of immune based therapies and vaccines · 2007Article
- Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection.Infection and immunity · 2007Article
- Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis.Clinical and experimental immunology · 2007Review
- Interferon-gamma and tumour necrosis factor-alpha production by CD4+ T and CD8+ T lymphocytes in AIDS patients with tuberculosis.Clinical and experimental immunology · 2005Article
- Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection.Infection and immunity · 2004Article
- TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.The Journal of clinical investigation · 2004Article
- Kinetics of changes in lymphocyte sub-populations in mouse lungs after intrapulmonary infection with M. bovis (Bacillus Calmette-Guerin) and identity of cells responsible for IFNgamma responses.Clinical and experimental immunology · 2002Article
- Murine model of BCG lung infection: dynamics of lymphocyte subpopulations in lung interstitium and tracheal lymph nodes.Journal of biosciences · 2002Article
- Familial CD8 deficiency due to a mutation in the CD8 alpha gene.The Journal of clinical investigation · 2001Article
- Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.Arthritis research · 2001Article
- Genetically determined disparate innate and adaptive cell-mediated immune responses to pulmonary Mycobacterium bovis BCG infection in C57BL/6 and BALB/c mice.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice deficient in CD8 T cells demonstrated levels of Th1 cytokines and granulomatous responses in the lungs very similar to those demonstrated by normal control mice and were fully capable of controlling pulmonary mycobacterial infection by Mycobacterium bovis BCG as assessed at day 37 postinfection. In comparison, mice deficient in CD4 T cells had similar levels of interleukin-12 (IL-12) and tumor necrosis factor alpha but lower levels of gamma interferon in the lungs and were still able to mount tissue granulomatous responses and control pulmonary mycobacterial infection. In contrast, IL-12(-/-) mice with impaired CD4 and CD8 T-cell responses had a markedly weakened control of infection, whereas SCID mice deficient in all T cells succumbed to such pulmonary mycobacterial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.