ArticleInfection and immunity1998
Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Innate receptors and cellular defense against pulmonary infections.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?Clinical & developmental immunology · 2012Review
- Tuberculosis immunity: opportunities from studies with cattle.Clinical & developmental immunology · 2011Review
- Roles of heat shock proteins and gamma delta T cells in inflammation.American journal of respiratory cell and molecular biology · 2008Review
- Host innate immune response to Mycobacterium tuberculosis.Journal of clinical immunology · 2007Review
- Pulmonary dendritic cells and alveolar macrophages are regulated by gammadelta T cells during the resolution of S. pneumoniae-induced inflammation.The Journal of pathology · 2007Article
- Failure of antigen-stimulated gammadelta T cells and CD4+ T cells from sensitized cattle to upregulate nitric oxide and mycobactericidal activity of autologous Mycobacterium avium subsp. paratuberculosis-infected macrophages.Veterinary immunology and immunopathology · 2007Article
- Characterization of the Histoplasma capsulatum-induced granuloma.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route.Infection and immunity · 2005Article
- Response of lung gammadelta T cells to experimental sepsis in mice.Immunology · 2004Article
- Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner.Infection and immunity · 2003Article
- Respiratory syncytial virus infection suppresses IFN-gamma production of gammadelta T cells.Clinical and experimental immunology · 2003Article
- Subset-specific reductions in lung lymphocyte accumulation following intratracheal antigen challenge in endothelial selectin-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2002Article
- Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity.Infection and immunity · 2002Article
- Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology.The Journal of experimental medicine · 2001Article
- Partners in crime: co-infections in the developing world.Clinical and experimental immunology · 2000Review
- Early nonspecific immune responses and immunity to blood-stage nonlethal Plasmodium yoelii malaria.Infection and immunity · 2000Article
- Invasion of the brain and chronic central nervous system infection after systemic Mycobacterium avium complex infection in mice.Infection and immunity · 2000Article
- Intraepithelial gamma delta T lymphocytes: sentinel cells at mucosal barriers.Springer seminars in immunopathology · 2000Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Several studies have shown that gamma delta T cells influence granuloma development after infection with intracellular pathogens. The role of gamma delta T cells in controlling the influx of inflammatory cells into the lung after Mycobacterium avium infection was therefore examined with gene-disrupted mice (K/O). The mice were infected with either M. avium 724, a progressively replicating highly virulent strain of M. avium, or with M. avium 2-151 SmT, a virulent strain that induces a chronic infection. gamma delta-K/O mice infected with M. avium 2-151 SmT showed early enhanced bacterial growth within the lung compared to the wild-type mice, although granuloma formation was similar in both strains. gamma delta-K/O mice infected with M. avium 724 showed identical bacterial growth within the lung compared to the wild-type mice, but they developed more-compact lymphocytic granulomas and did not show the extensive neutrophil influx and widespread tissue necrosis seen in wild-type mice. These data support the hypothesis that isolates of M. avium that induce protective T-cell-specific immunity are largely unaffected by the absence of gammadelta T cells. Whereas with bacterial strains that induce poor protective immunity, the absence of gamma delta T cells led to significant reductions in both the influx of neutrophils and tissue damage within the lungs of infected mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.