ArticleInfection and immunity1998
Oral immunization with a Salmonella typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody titers for protective immunity.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Coimmunization with Two Enterotoxigenic Escherichia coli (ETEC) Fimbrial Multiepitope Fusion Antigens Induces the Production of Neutralizing Antibodies against Five ETEC Fimbriae (F4, F5, F6, F18, and F41).Applied and environmental microbiology · 2020Article
- Expression fusion immunogen by live attenuated Escherichia coli against enterotoxins infection in mice.Microbial biotechnology · 2019Article
- Animal Enterotoxigenic Escherichia coli.EcoSal Plus · 2016Review
- Generation of Salmonella ghost cells expressing fimbrial antigens of enterotoxigenic Escherichia coli and evaluation of their antigenicity in a murine model.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2016Article
- A vaccine candidate for post-weaning diarrhea in swine constructed with a live attenuated Salmonella delivering Escherichia coli K88ab, K88ac, FedA, and FedF fimbrial antigens and its immune responses in a murine model.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2012Article
- Role of overexpressed CFA/I fimbriae in bacterial swimming.Physical biology · 2012Article
- Capture efficiency of Escherichia coli in fimbriae-mediated immunoimmobilization.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Serum antibodies protect against intraperitoneal challenge with enterotoxigenic Escherichia coli.Journal of biomedicine & biotechnology · 2011Article
- Platform technology to deliver prophylactic molecules orally: an example using the Class A select agent Yersinia pestis.Vaccine · 2010Article
- Immune response to Lactobacillus plantarum expressing Borrelia burgdorferi OspA is modulated by the lipid modification of the antigen.PloS one · 2010Article
- A one-plasmid system to generate influenza virus in cultured chicken cells for potential use in influenza vaccine.Journal of virology · 2009Article
- Oral immunization with recombinant lactobacillus plantarum induces a protective immune response in mice with Lyme disease.Clinical and vaccine immunology : CVI · 2008Article
- Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Tolerance in the absence of autoantigen.Endocrine, metabolic & immune disorders drug targets · 2007Review
- Chloroplast targeting of FanC, the major antigenic subunit of Escherichia coli K99 fimbriae, in transgenic soybean.Plant cell reports · 2007Article
- Article
- Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure.Infection and immunity · 2007Article
- Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Hypophysectomy and neurointermediate pituitary lobectomy reduce serum immunoglobulin M (IgM) and IgG and intestinal IgA responses to Salmonella enterica serovar Typhimurium infection in rats.Infection and immunity · 2006Article
- Partially assembled K99 fimbriae are required for protection.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Bovine enterotoxigenic Escherichia coli (ETEC) continues to cause mortality in piglets and newborn calves. In an effort to develop a safe and effective vaccine for the prevention of F5(+) ETEC infections, a balanced lethal asd+ plasmid carrying the complete K99 operon was constructed and designated pMAK99-asd+. Introduction of this plasmid into an attenuated Salmonella typhimurium Deltaaro Deltaasd strain, H683, resulted in strain AP112, which stably expresses E. coli K99 fimbriae. A single oral immunization of BALB/c and CD-1 mice with strain AP112 elicited significant mucosal immunoglobulin A (IgA) titers that remained elevated for >11 weeks. IgA and IgG responses in serum specific for K99 fimbriae were also induced, with a prominent IgG1, as well as IgG2a and IgG2b, titer. To assess the derivation of these antibodies, a K99 isotype-specific B-cell ELISPOT analysis was conducted by using mononuclear cells from the lamina propria of the small intestines (LP), Peyer's patches (PP), and spleens of vaccinated and control BALB/c mice. This analysis revealed elevated numbers of K99 fimbria-specific IgA-producing cells in the LP, PP, and spleen, whereas elevated K99 fimbria-specific IgG-producing cells were detected only in the PP and spleen. These antibodies were important for protective immunity. One-day-old neonates from dams orally immunized with AP112 were provided passive protection against oral challenge with wild-type ETEC, in contrast to challenged neonates from unvaccinated dams or from dams vaccinated with a control Salmonella vector. These results confirm that oral Salmonella vaccine vectors effectively deliver K99 fimbriae to mucosal inductive sites for sustained elevation of IgA and IgG antibodies and for eliciting protective immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.