ArticleInfection and immunity1998
Impact of M49, Mrp, Enn, and C5a peptidase proteins on colonization of the mouse oral mucosa by Streptococcus pyogenes.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- A mini review of the pathogenesis of acute rheumatic fever and rheumatic heart disease.Frontiers in cellular and infection microbiology · 2025Review
- Efficient and rapid one-step method to generate gene deletions inMicrobiology spectrum · 2024Article
- Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.PLoS pathogens · 2017Article
- Co-Activation of Th17 and Antibody Responses Provides Efficient Protection against Mucosal Infection by Group A Streptococcus.PloS one · 2016Article
- The AgI/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes.PloS one · 2013Article
- Conserved anchorless surface proteins as group A streptococcal vaccine candidates.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococci.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Human serum induces streptococcal c5a peptidase expression.Infection and immunity · 2009Article
- A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response.Infection and immunity · 2008Article
- Mga is sufficient to activate transcription in vitro of sof-sfbX and other Mga-regulated virulence genes in the group A Streptococcus.Journal of bacteriology · 2006Article
- Surface analyses and immune reactivities of major cell wall-associated proteins of group a streptococcus.Infection and immunity · 2005Article
- Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes.Infection and immunity · 2005Article
- The M protein is dispensable for maturation of streptococcal cysteine protease SpeB.Infection and immunity · 2005Article
- Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens.Clinical microbiology reviews · 2005Review
- Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.Infection and immunity · 2004Article
- Extracellular enzymes with immunomodulating activities: variations on a theme in Streptococcus pyogenes.Infection and immunity · 2003Review
- Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood.Infection and immunity · 2003Article
- Immunization with C5a peptidase or peptidase-type III polysaccharide conjugate vaccines enhances clearance of group B Streptococci from lungs of infected mice.Infection and immunity · 2002Article
- Structural heterogeneity of the streptococcal C5a peptidase gene in Streptococcus pyogenes.Journal of bacteriology · 2002Article
- M(+) group a streptococci are phagocytized and killed in whole blood by C5a-activated polymorphonuclear leukocytes.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Resistance to phagocytosis is a hallmark of virulent Streptococcus pyogenes (group A streptococcus). Surface-bound C5a peptidase reduces recruitment of phagocytes to the site of infection, and hyaluronic acid capsules and/or the M protein limit the uptake of streptococci. In this study the relative impact of M and M-like proteins and the C5a peptidase on the virulence of a serotype M49 strain was assessed. The capacities of isogenic strains with an insertion mutation in emm49; with a deletion mutation in scpA49 (C5a peptidase gene); and with a deletion that removes all three M-like genes, mrp49, emm49, and enn49, to colonize mice and resist phagocytosis were compared. Experiments confirmed results obtained in an earlier study, which showed that the M49 protein was not required for in vitro resistance to phagocytosis, and also showed that the M protein was not required for colonization of mice. Failure to produce all three M-like proteins, M49, Mrp, and Enn49, significantly reduced the ability of these streptococci to resist phagocytosis in vitro but did not significantly alter the persistence of streptococci on the oral mucosa. In vitro experiments indicate that M+ streptococci are phagocytized by polymorphonuclear leukocytes that have been activated with phorbol-12-myristate 13-acetate or recombinant human C5a. This observation may explain the finding that expression of M49 protein is not essential for short-term colonization of the mouse oral mucosa.
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