ArticleInfection and immunity1998
Diversity of antigen recognition by serum antibodies in experimental bovine tuberculosis.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 91 citations in OpenAlex.
- Comparative Evaluation of ELISA Tests for Bovine Tuberculosis Detection: Implications for Improved Disease Control.Transboundary and emerging diseases · 2026Article
- B Cell and Antibody Responses in Bovine Tuberculosis.Antibodies (Basel, Switzerland) · 2024Review
- Article
- Comparing recombinant MPB70/SahH and native 20-kDa protein for detecting bovine tuberculosis using ELISA.The Journal of veterinary medical science · 2020Article
- Review
- ELISA using a recombinant chimera of ESAT-6/MPB70/MPB83 for Mycobacterium bovis diagnosis in naturally infected cattle.The Journal of veterinary medical science · 2019Article
- Modeling the Accuracy of TwoFrontiers in veterinary science · 2019Article
- Identification of Novel Antigens Recognized by Serum Antibodies in Bovine Tuberculosis.Clinical and vaccine immunology : CVI · 2017Article
- The Kinetics of the Humoral and Interferon-Gamma Immune Responses to ExperimentalFrontiers in immunology · 2017Article
- Isolation of mycobacteria from clinical samples collected in the United States from 2004 to 2011.BMC veterinary research · 2013Article
- Screening of recombinant proteins as antigens in indirect ELISA for diagnosis of bovine tuberculosis.SpringerPlus · 2012Article
- Bovine tuberculosis in cattle in the highlands of cameroon: seroprevalence estimates and rates of tuberculin skin test reactors at modified cut-offs.Veterinary medicine international · 2012Article
- Article
- Single-antigen serological testing for bovine tuberculosis.Clinical and vaccine immunology : CVI · 2009Article
- Highly accurate antibody assays for early and rapid detection of tuberculosis in African and Asian elephants.Clinical and vaccine immunology : CVI · 2009Article
- Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattle.Clinical and vaccine immunology : CVI · 2008Article
- Antibody responses of cervids (Cervus elaphus) following experimental Mycobacterium bovis infection and the implications for immunodiagnosis.Clinical and vaccine immunology : CVI · 2008Article
- Comparison of the proteosomes and antigenicities of secreted and cellular proteins produced by Mycobacterium paratuberculosis.Clinical and vaccine immunology : CVI · 2006Article
- Tuberculosis in elephants: antibody responses to defined antigens of Mycobacterium tuberculosis, potential for early diagnosis, and monitoring of treatment.Clinical and vaccine immunology : CVI · 2006Article
- Antibody responses in reindeer (Rangifer tarandus) infected with Mycobacterium bovis.Clinical and diagnostic laboratory immunology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tuberculosis in cattle remains a major zoonotic and economic problem in many countries. The standard diagnostic assay for bovine tuberculosis, the intradermal tuberculin test, has low accuracy. Therefore, alternative immunodiagnostic methods, such as serological assays, are needed for detection of infected animals. Development of an accurate serodiagnostic test requires a detailed understanding of the humoral immune responses during bovine tuberculosis and, in particular, identification of the key antigens of Mycobacterium bovis involved in antibody production. In this study, we characterized antibody responses in cattle experimentally infected with M. bovis. Sequential serum samples were collected every 3 to 4 weeks for up to 27 months postinfection. Circulating immunoglobulin G antibody levels were measured by an enzyme-linked immunosorbent assay using 12 highly purified recombinant proteins of M. bovis. Six proteins, ESAT-6, 14-kDa protein, MPT63, MPT70, MPT51, and MPT32, were identified as major seroreactive antigens in bovine tuberculosis. A remarkable animal-to-animal variation of antigen recognition by serum antibodies was observed. Kinetic analyses of the antibody production to individual antigens during infection revealed that the heterogeneous antigen recognition profile changed markedly in a given infected animal as disease progressed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.