Evidence map›Paper›PMID 9783435›Full record

ReviewInvertebrate neuroscience : IN

Neuromuscular glutamatergic and GABAergic channels.

J Dudel, H Adelsberger, M Heckmann

Abstract readReview
PubMed Publisher
In one paragraph

Review in Invertebrate neuroscience : IN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J DudelPhysiologisches Institut, Technischen Universität München, Germany. Dudel: dudel@physiol.med.tu-muenchen.de
H Adelsberger
M Heckmann
Ludwig-Maximilians-Universität München · DEMunich University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our laboratory has worked extensively on glutamatergic and GABA-ergic channels, predominantly in crayfish, but also in locust, Drosophila and recently Ascaris. Channel currents were recorded in the different modes of the patch-clamp technique (Hamill et al., 1981). The opening kinetics of the channels were derived from open and closed time histograms obtained from single channel recordings. From these, channel conductances could also be evaluated. The most relevant data were obtained by very rapidly rising and falling pulses (time of change about 0.1 ms) of agonists applied to outside-out patches containing the respective channels (Franke et al., 1987). From such recordings we constructed dose-response curves for peak and steady-state currents, for the rise times of the currents and for the time constants of desensitization. In double-pulse experiments we measured recovery from desensitization and predesensitization due to low agonist concentrations. For most of the channel types, we succeeded in constructing a reaction scheme which in computer simulations mimicked channel behaviour to a good approximation.

Indexed as

AnimalsAscarisAstacoideaChloride ChannelsComputer SimulationDrosophilagamma-Aminobutyric AcidGlutamic AcidGrasshoppersIon ChannelsMathematicsModels, NeurologicalNephropidaeNeuromuscular JunctionSynapsesChloride Channelsgamma-Aminobutyric AcidGlutamic AcidIon Channels

Identifiers

PMID9783435
OpenAlexW2057245694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.