ArticleThe Journal of physiology1998
Facilitation of presynaptic calcium currents in the rat brainstem.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 167 citations in OpenAlex.
- A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse.eLife · 2024Article
- Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process.The Journal of general physiology · 2024Article
- A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Population temporal structure supplements the rate code during sensorimotor transformations.Current biology : CB · 2022Article
- Article
- Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex.Frontiers in synaptic neuroscience · 2021Article
- Calcium Channel Splice Variants and Their Effects in Brain and Cardiovascular Function.Advances in experimental medicine and biology · 2021Article
- Diverse roles of Synaptotagmin-7 in regulating vesicle fusion.Current opinion in neurobiology · 2020Review
- Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:CaeLife · 2020Article
- The Role of CaCell reports · 2019Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dynamics of volume-averaged intracellular CaThe Journal of physiology · 2017Article
- Review
- The calyx of Held in the auditory system: Structure, function, and development.Hearing research · 2016Review
- Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing.Cerebellum (London, England) · 2016Article
- Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells.The Journal of physiology · 2015Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. To study use-dependent changes in the presynaptic Ca2+ influx and their contribution to transmitter release, we made simultaneous voltage clamp recordings from presynaptic terminals (the calyces of Held) and postsynaptic cells (the principal cells of the medial nucleus of the trapezoid body) in slices of the rat auditory brainstem. 2. Following a short (2 ms) prepulse to 0 mV, calcium channels opened faster during steps to negative test potentials. During trains of action potential waveforms the Ca2+ influx per action potential increased. At the same time, however, the amplitude of the EPSCs decreased. 3. The facilitation of the calcium currents appeared to depend on a build-up of intracellular Ca2+, since its magnitude was proportional to the Ca2+ influx and it was reduced in the presence of 10 mM BAPTA. 4. Facilitation of the presynaptic calcium currents may contribute to short-term facilitation of transmitter release, observed when quantal output is low. Alternatively, it may counteract processes that contribute to synaptic depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.