ArticleThe Journal of experimental medicine1998
Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Functionalized Lipid Droplets and Microfluidics Approach to Study Immune Cell Polarity In Vitro.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells.Frontiers in cell and developmental biology · 2021Review
- Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Review: Bioengineering strategies to probe T cell mechanobiology.APL bioengineering · 2018Review
- TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells.Frontiers in immunology · 2018Article
- Article
- Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.Scientific reports · 2015Article
- Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?Frontiers in immunology · 2015Review
- Understanding HIV latency: the road to an HIV cure.Annual review of medicine · 2015Review
- Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.Science translational medicine · 2014Article
- The infectious synapse formed between mature dendritic cells and CD4(+) T cells is independent of the presence of the HIV-1 envelope glycoprotein.Retrovirology · 2013Article
- Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS).PLoS computational biology · 2013Article
- Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.The Journal of biological chemistry · 2012Article
- CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells.PloS one · 2012Article
- Relative efficacy of uptake and presentation of Mycobacterium bovis BCG antigens by type I mouse lung epithelial cells and peritoneal macrophages.Infection and immunity · 2011Article
- Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells.Cell death and differentiation · 2011Article
- GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Perspectives for computer modeling in the study of T cell activation.Cold Spring Harbor perspectives in biology · 2010Review
- T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are much more potent antigen (Ag)-presenting cells than resting B cells for the activation of naive T cells. The mechanisms underlying this difference have been analyzed under conditions where ex vivo DCs or B cells presented known numbers of specific Ag-major histocompatibility complex (MHC) complexes to naive CD4(+) T cells from T cell antigen receptor (TCR) transgenic mice. Several hundred Ag-MHC complexes presented by B cells were necessary to elicit the formation of a few T-B conjugates with small contact zones, and the resulting individual T cell Ca2+ responses were all-or-none. In contrast, Ag-specific T cell Ca2+ responses can be triggered by DCs bearing an average of 30 Ag-MHC complexes per cell. Formation of T-DC conjugates is Ag-independent, but in the presence of the Ag, the surface of the contact zone increases and so does the amplitude of the T cell Ca2+ responses. These results suggest that Ag is better recognized by T cells on DCs essentially because T-DC adhesion precedes Ag recognition, whereas T-B adhesion requires Ag recognition. Surprisingly, we also recorded small Ca2+ responses in T cells interacting with unpulsed DCs. Using DCs purified from MHC class II knockout mice, we provide evidence that this signal is mostly due to MHC-TCR interactions. Such an Ag-independent, MHC-triggered calcium response could be a survival signal that DCs but not B cells are able to deliver to naive T cells.
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