ArticleThe Journal of experimental medicine1998
Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 142 citations in OpenAlex.
- The role of IL-2 in type 2 immunity.Frontiers in immunology · 2025Review
- B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates.Cell reports · 2022Article
- The C3d-fused foot-and-mouth disease vaccine platform overcomes maternally-derived antibody interference by inducing a potent adaptive immunity.NPJ vaccines · 2022Article
- Role of B cells as antigen presenting cells.Frontiers in immunology · 2022Review
- A cell-based in vitro assay for testing of immunological integrity of Tetanus toxoid vaccine antigen.NPJ vaccines · 2021Article
- Article
- HIV-1 VRC01 Germline-Targeting Immunogens Select Distinct Epitope-Specific B Cell Receptors.Immunity · 2020Article
- Role of nanoscale antigen organization on B-cell activation probed using DNA origami.Nature nanotechnology · 2020Article
- BCR-Induced CaCell reports · 2020Article
- Review
- Article
- Programming Structured DNA Assemblies to Probe Biophysical Processes.Annual review of biophysics · 2019Review
- Loss of an IgG plasma cell checkpoint in patients with lupus.The Journal of allergy and clinical immunology · 2019Article
- Multivalent Antigens for Promoting B and T Cell Activation.ACS chemical biology · 2015Article
- Antibody-independent functions of B cells: a focus on cytokines.Nature reviews. Immunology · 2015Review
- Memory B cells in transplantation.Transplantation · 2015Review
- Tumor-derived autophagosomes (DRibbles) induce B cell activation in a TLR2-MyD88 dependent manner.PloS one · 2013Article
- Anti-HIV B Cell lines as candidate vaccine biosensors.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Formation of BCR oligomers provides a mechanism for B cell affinity discrimination.Journal of theoretical biology · 2012Article
- Discrimination of membrane antigen affinity by B cells requires dominance of kinetic proofreading over serial engagement.Cellular & molecular immunology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The B cell receptor (BCR) triggers a variety of biological responses that differ depending upon the properties of the antigen. A panel of M13 phage-displayed peptide ligands with varying affinity for the 3-83 antibody was generated to explore the role of antigen-BCR affinity in cell activation studies using primary 3-83 transgenic mouse B cells. Multiple parameters of activation were measured. T cell-independent B cell proliferation, antibody secretion, induction of germline immunoglobulin gamma1 transcripts, and B cell production of interleukin (IL) 2 and interferon gamma responses were better correlated with antigen-BCR affinity than with receptor occupancy. In contrast, other responses, such as upregulation of major histocompatibility complex class II and B7.2 (CD86), secretion of IL-6, and B cell proliferation in the context of CD40 signaling were only weakly dependent on antigen affinity. Biochemical analysis revealed that at saturating ligand concentrations the ability of phage to stimulate some early signaling responses, such as Ca++ mobilization and tyrosine phosphorylation of syk or Igalpha, was highly affinity dependent, whereas the ability to stimulate Lyn phosphorylation was less so. These data suggest that the BCR is capable of differential signaling. The possibility that differential BCR signaling by antigen determines whether an antibody response will be T independent or dependent is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.