ArticleCurrent biology : CB1998
A nematode kinesin required for cleavage furrow advancement.
Article in Current biology : CB, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 171 citations in OpenAlex.
- Centralspindlin-mediated transport of RhoGEF positions the cleavage plane for cytokinesis.Science signaling · 2023Article
- Article
- Mechanistic insights into central spindle assembly mediated by the centralspindlin complex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Male meiotic spindle features that efficiently segregate paired and lagging chromosomes.eLife · 2020Article
- Review
- Strategies for Efficient Genome Editing Using CRISPR-Cas9.Genetics · 2019Article
- Article
- Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP, and PAR-6.Molecular biology of the cell · 2017Article
- A GAP that Divides.F1000Research · 2017Review
- Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor.Nature communications · 2016Article
- Kinetochore components are required for central spindle assembly.Nature cell biology · 2015Article
- CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.PLoS biology · 2015Article
- New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies.Frontiers in oncology · 2015Review
- Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.The Journal of biological chemistry · 2013Article
- Centralspindlin: at the heart of cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Molecular control of animal cell cytokinesis.Nature cell biology · 2012Review
- The RhoGAP domain of CYK-4 has an essential role in RhoA activation.Current biology : CB · 2012Article
- Initial diameter of the polar body contractile ring is minimized by the centralspindlin complex.Developmental biology · 2011Article
- Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.The Journal of cell biology · 2011Article
- The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.The Journal of cell biology · 2011Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Dividing cells need to coordinate the separation of chromosomes with the formation of a cleavage plane. There is evidence that microtubule bundles in the interzone region of the anaphase spindle somehow control both the location and the assembly of the cleavage furrow [1-3]. A microtubule motor that concentrates in the interzone, MKLP1, has previously been implicated in the assembly of both the metaphase spindle and the cleavage furrow [4-6]. To gain insight into mechanisms that might underlie interdependence of the spindle and the cleavage furrow, we used RNA-mediated interference (RNAi) to study the effects of eliminating MKLP1 from Caenorhabditis elegans embryos. Surprisingly, in MKLP1(RNAi) embryos, spindle formation appears normal until late anaphase. Microtubule bundles form in the spindle interzone and the cleavage furrow assembles; anaphase and cleavage furrow ingression initially appear normal. The interzone bundles do not gather into a stable midbody, however, and furrow contraction always fails before complete closure. This sequence of relatively normal mitosis and a late failure of cytokinesis continues for many cell cycles. These and additional results suggest that the interzone microtubule bundles need MKLP1 to encourage the advance and stable closure of the cleavage furrow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.