Evidence map›Paper›PMID 9777952›Full record

ReviewThe American journal of pathology1998

The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes.

C Oliveira, R Seruca, M Seixas, M Sobrinho-Simões

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 146 citations in OpenAlex.

  1. Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Review
  2. Finding the hot spot: identifying immune sensitive gastrointestinal tumors.Translational gastroenterology and hepatology · 2020
    Review
  3. Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric CancerAsian Pacific journal of cancer prevention : APJCP · 2019
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Gastric biomarkers: a global review.World journal of surgical oncology · 2016
    Review
  9. Article
  10. Review
  11. Immunohistochemical expression pattern of MMR protein can specifically identify patients with colorectal cancer microsatellite instability.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
  12. Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?Virchows Archiv : an international journal of pathology · 2014
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Implication of microsatellite instability in human gastric cancers.The Indian journal of medical research · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C OliveiraInstitute of Molecular Pathology and Immunology of the University of Porto, Portugal.
R Seruca
M Seixas
M Sobrinho-Simões
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric carcinomas with DNA replication errors (RER phenotype) display a particular clinicopathologic profile and carry a putative favorable prognosis. The RER phenotype has been identified as microsatellite instability in noncoding regions, as well as in repeat sequences within exons of several "target genes": TGFbeta RII, IGFII R, and BAX. In an attempt to find out whether the RER status is a significant prognostic factor in gastric carcinoma in a multivariate analysis and whether the clinicopathological features of the RER+ tumors are associated with mutations in the "target genes," we evaluated a series of 152 cases of sporadic gastric carcinoma. Five or six microsatellite loci and/or BAT 26, a poly(A) tract, were analyzed in each case using polymerase chain reaction and electrophoresis. Thirty-five cases (23.0%) were RER+. The RER phenotype was closely associated with a low pTNM stage and carried a significantly better prognosis. The repeat sequences of the target genes were screened for mutations in 28 RER+ and 13 RER-tumors. Mutations in TGFbeta RII occurred in 67.9% of the RER+ tumors and were significantly associated with the glandular histotype. IGFII R and BAX mutations occurred, respectively, in 25.0% and 32.1% of the cases; there was a trend toward an association between mutations in these genes and decreased nodal metastization and wall invasiveness, respectively. We conclude that the RER status is a significant prognostic indicator in gastric carcinoma and that such prognostic influence may be mediated by mutations in TGFbeta RII, IGFII R, and BAX genes.

Indexed as

MutationProto-Oncogene Proteins c-bcl-2Agedbcl-2-Associated X ProteinDNA, NeoplasmDNA PrimersDNA RepairDNA ReplicationDNA, SatelliteFemaleGenetic MarkersHumansHypoxanthine PhosphoribosyltransferaseMaleMicrosatellite RepeatsMiddle AgedBAX protein, humanbcl-2-Associated X ProteinDNA, NeoplasmDNA PrimersDNA, SatelliteGenetic MarkersHypoxanthine PhosphoribosyltransferaseProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Receptor, IGF Type 2Receptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type II

Identifiers

PMID9777952
PMCPMC1853052
OpenAlexW1669049638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.