ArticleMolecular and cellular biology1998
Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicing.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- The E193K LRRK2 mutation interferes with the autophagosome processing through the impairment of the LRRK2-Dynein-1 complex.Scientific reports · 2025Article
- Review
- On the genetic basis of the effect of Spiroplasma on the male reproductive fitness of Glossina fuscipes fuscipes.PLoS pathogens · 2022Article
- Rapid Functional and Sequence Differentiation of a Tandemly Repeated Species-Specific Multigene Family in Drosophila.Molecular biology and evolution · 2017Article
- Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.Experimental cell research · 2015Review
- The Drosophila MAST kinase Drop out is required to initiate membrane compartmentalisation during cellularisation and regulates dynein-based transport.Development (Cambridge, England) · 2014Article
- Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.International journal of molecular sciences · 2013Article
- Functional relevance of the newly evolved sperm dynein intermediate chain multigene family in Drosophila melanogaster males.Communicative & integrative biology · 2012Article
- Novel genes from formation to function.International journal of evolutionary biology · 2012Article
- Structural dynamics and multiregion interactions in dynein-dynactin recognition.The Journal of biological chemistry · 2011Article
- Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm.BMC genomics · 2011Article
- Light chain-dependent self-association of dynein intermediate chain.The Journal of biological chemistry · 2011Article
- Article
- Article
- The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly.The Journal of biological chemistry · 2010Article
- Genetic analysis of the cytoplasmic dynein subunit families.PLoS genetics · 2006Article
- Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar.Molecular biology of the cell · 2005Article
- The offloading model for dynein function: differential function of motor subunits.The Journal of cell biology · 2005Article
- No statistical support for correlation between the positions of protein interaction sites and alternatively spliced regions.BMC bioinformatics · 2004Article
- The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila.Genetics · 2002Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermediate chains (ICs) are the subunits of the cytoplasmic dynein that provide binding of the complex to cargo organelles through interaction of their N termini with dynactin. We present evidence that in Drosophila, the IC subunits are represented by at least 10 structural isoforms, created by the alternative splicing of transcripts from a unique Cdic gene. The splicing pattern is tissue specific. A constitutive set of four IC isoforms is expressed in all tissues tested; in addition, tissue-specific isoforms are found in the ovaries and nervous tissue. The structural variations between isoforms are limited to the N terminus of the IC molecule, where the interaction with dynactin takes place. This suggests differences in the dynactin-mediated organelle binding by IC isoforms. Accordingly, when transiently expressed in Drosophila Schneider-3 cells, the IC isoforms differ in their intracellular targeting properties from each other. A mechanism is proposed for the regulation of dynein binding to organelles through the changes in the content of the IC isoform pool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.