ArticleMolecular and cellular biology1998
Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Coregulatory Networks Remodel the Disease-Specific Functions of Orphan Nuclear Receptor TR4.Cells · 2026Review
- Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions.International journal of molecular sciences · 2021Review
- Non-canonical Estrogen Signaling in Endocrine Resistance.Frontiers in endocrinology · 2019Review
- Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia.Molecular neurobiology · 2016Article
- Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation.Brain, behavior, and immunity · 2015Article
- Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.PLoS genetics · 2015Article
- RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages.Journal of molecular and cellular cardiology · 2015Article
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death.Nature communications · 2014Article
- Minireview: the diverse roles of nuclear receptors in the regulation of embryonic stem cell pluripotency.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Biological activities of receptor-interacting protein 140 in adipocytes and metabolic diseases.Current diabetes reviews · 2012Review
- NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.Nature immunology · 2012Article
- Chromatin remodeling and epigenetic regulation of the CrabpI gene in adipocyte differentiation.Biochimica et biophysica acta · 2012Review
- General molecular biology and architecture of nuclear receptors.Current topics in medicinal chemistry · 2012Review
- Gene repressive activity of RIP140 through direct interaction with CDK8.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Role of nuclear receptor corepressor RIP140 in metabolic syndrome.Biochimica et biophysica acta · 2011Review
- Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Molecular and cellular biology · 2011Article
- Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms.Journal of molecular endocrinology · 2011Article
- Nuclear receptor coregulators as a new paradigm for therapeutic targeting.Advanced drug delivery reviews · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The mouse homologue of the human receptor-interacting protein 140 (RIP140) was isolated from a mouse embryonic cDNA library in yeast two-hybrid screening experiments by using the ligand binding domain (LBD) of nuclear orphan receptor TR2 as the bait. The receptor-interacting domains of mouse RIP140 were mapped to the regions containing the LXXLL motif (where L is leucine and X is any amino acid), and the RIP140-interacting domain of TR2 was mapped to its C-terminal 10- to 20-amino-acid sequence, a putative activation function 2 (AF-2) region. In a GAL4 reporter system and a reporter driven by the proximal region of the TR2 promoter, RIP140 functioned as a corepressor for both a GAL4 DNA binding domain (BD)-TR2 fusion and the wild-type receptor. When tethered to the BD of GAL4, RIP140 exerted a trans-repressive effect on the GAL4 reporter. In addition, RIP140 suppressed the retinoic acid (RA) receptor-mediated RA induction in a dose-dependent manner. Finally, it was demonstrated that in the presence of RIP140, a cytosolic, green fluorescent protein-tagged TR2 LBD translocated into the nucleus, and TR2 and RIP140 were coimmunoprecipitated from the cell extract, indicating that the interaction between RIP140 and the LBD of TR2 occurred in vivo. The potential biological role of RIP140 in TR2-modulated transcriptional activity is discussed.
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