ArticleMolecular and cellular biology1998
Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
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- Strategies to therapeutically modulate cytokine action.Nature reviews. Drug discovery · 2023Review
- Somatic Mutations Alter Interleukin Signaling Pathways in Grade II Invasive Breast Cancer Patients: An Egyptian Experience.Current issues in molecular biology · 2022Article
- Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells.Molecular medicine reports · 2021Article
- Regulatory T Cells: From Discovery to Autoimmunity.Cold Spring Harbor perspectives in medicine · 2018Review
- Signaling and Function of Interleukin-2 in T Lymphocytes.Annual review of immunology · 2018Review
- PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity.Frontiers in immunology · 2018Review
- Molecular mechanisms underlying Th1-like Treg generation and function.Cellular and molecular life sciences : CMLS · 2017Review
- Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2017Article
- AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.EMBO reports · 2016Article
- Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network.Cellular and molecular life sciences : CMLS · 2015Review
- Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.Science signaling · 2012Article
- JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth.Growth factors (Chur, Switzerland) · 2011Review
- Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor.The Biochemical journal · 2011Review
- Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- PIP3 pathway in regulatory T cells and autoimmunity.Immunologic research · 2007Review
- IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Oncogenic kinase signalling.Nature · 2001Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidylinositol 3-kinase (PI 3-K) plays an important role in signaling via a wide range of receptors such as those for antigen, growth factors, and a number of cytokines, including interleukin-2 (IL-2). PI 3-K has been implicated in both IL-2-induced proliferation and prevention of apoptosis. A number of potential mechanisms for the recruitment of PI 3-K to the IL-2 receptor have been proposed. We now have found that tyrosine residues in the IL-2 receptor beta chain (IL-2Rbeta) are unexpectedly not required for the recruitment of the p85 component of PI 3-K. Instead, we find that Jak1, which associates with membrane-proximal regions of the IL-2Rbeta cytoplasmic domain, is essential for efficient IL-2Rbeta-p85 interaction, although some IL-2Rbeta-p85 association can be seen in the absence of Jak1. We also found that Jak1 interacts with p85 in the absence of IL-2Rbeta and that IL-2Rbeta and Jak1 cooperate for the efficient recruitment and tyrosine phosphorylation of p85. This is the first report of a PI 3-K-Jak1 interaction, and it implicates Jak1 in an essential IL-2 signaling pathway distinct from the activation of STAT proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.