Evidence map›Paper›PMID 9774574›Full record

ArticleJournal of clinical microbiology1998

Comparison of PCR- and hybrid capture-based human papillomavirus detection systems using multiple cervical specimen collection strategies.

C L Peyton, M Schiffman, A T Lörincz, W C Hunt, I Mielzynska, C Bratti, S Eaton, A Hildesheim, L A Morera, A C Rodriguez and 3 more

Erratum issuedOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Search for Equus caballus papillomavirus type 2 in tissues of asymptomatic horses in southern brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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  18. Specific magnetic isolation for direct detection of HPV16.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

C L PeytonDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico, USA.
M Schiffman
A T Lörincz
W C Hunt
I Mielzynska
C Bratti
S Eaton
A Hildesheim
L A Morera
A C Rodriguez
R Herrero
M E Sherman
C M Wheeler
Costa Rican Department of Social Security · CRUniversity of New Mexico · USCancer Institute (WIA) · INJohns Hopkins University · US

Funding

NCI NIH HHS RFP-NCI-CA-CN-55044-07
6 · The paper itself

Abstract

This study compared the performances of three human papillomavirus (HPV) detection tests with specimens collected by three alternative procedures. The HPV tests included the Hybrid Capture Tube test (HCT), the microplate-based Hybrid Capture II test (HC II), and the MY09-MY11 L1 consensus primer PCR-based assay. Initial cervical specimens were collected from study subjects with a broom device, and after Papanicolaou smears were made, residual specimens were placed into PreservCyt (PC), a liquid cytology medium. A second specimen was collected from each subject and placed into Digene Specimen Transport Medium (STM). The device for collection of the second specimen alternated with consecutive subjects between a conical cytology brush and a Dacron swab. At the 1.0-pg/ml cutoff, the results of the HC II agreed well with those of the PCR. Specifically, when PCR data were restricted to the types found by the HC II (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68), there was greater than 90% agreement between the HC II and PCR results with both STM and PC. At a lower cutoff (0.2 pg/ml), HC II-positive results increased further, especially when the test was applied to the PC specimens. However, false-positive HC II results were more often observed at the 0.2-pg/ml cutoff. HC II yielded the highest HPV positivity with specimens placed into PC, followed by specimens collected with a conical brush and placed into STM and, last, by those collected with a Dacron swab and placed into STM. Our results demonstrate the utility of both the STM and PC specimen collection methods and show good agreement between the HC II and PCR.

Indexed as

AdultCervix UteriDiagnostic ErrorsDNA Probes, HPVDNA, ViralEvaluation Studies as TopicFemaleHumansPapillomaviridaePapillomavirus InfectionsPolymerase Chain ReactionSensitivity and SpecificityTumor Virus InfectionsUterine CervicitisVirologyDNA Probes, HPVDNA, Viral

Identifiers

PMID9774574
PMCPMC105310
OpenAlexW2142068436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.