Evidence map›Paper›PMID 9774561›Full record

ArticleJournal of clinical microbiology1998

Enzyme-linked immunosorbent assay based on recombinant human group C rotavirus inner capsid protein (VP6) To detect human group C rotaviruses in fecal samples.

V L James, P R Lambden, E O Caul, I N Clarke

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Animals : an open access journal from MDPI · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Viruses causing gastroenteritis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2003
    Review
  8. Article
  9. Article
  10. Seroepidemiology of human group C rotavirus in South Africa.Journal of clinical microbiology · 1999
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

V L JamesPublic Health Laboratory, Southampton General Hospital, Southampton SO16 6YD, United Kingdom. vlaj@soton.ac.uk
P R Lambden
E O Caul
I N Clarke
Public Health LaboratorySouthampton General Hospital · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent study showed that 43% of a population in the United Kingdom were seropositive for group C rotavirus. The higher than expected incidence may be due to limited diagnosis of acute human group C rotavirus infections because no routine test is available. Human group C rotavirus infections are routinely diagnosed by electron microscopy (EM) and a negative group A rotavirus enzyme-linked immunosorbent assay (ELISA) result. An antigen-detection ELISA was developed with hyperimmune antibodies raised to human group C rotavirus recombinant VP6 (Bristol strain) expressed in insect cells. The assay was used to screen fecal samples to determine the prevalence of group C rotavirus infection. Samples positive by ELISA were confirmed by EM, polyacrylamide gel electrophoresis of double-stranded RNA, or detection of the VP6 gene by reverse transcription-PCR. Retrospective analysis indicated a 1 to 2% detection rate of positivity among samples from patients with acute diarrhea.

Indexed as

Capsid ProteinsAnimalsAntibodies, ViralAntigens, ViralBase SequenceCapsidDiarrheaDNA PrimersElectrophoresis, Polyacrylamide GelEnzyme-Linked Immunosorbent AssayFecesHumansMicroscopy, ElectronRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, ViralAntibodies, ViralAntigens, ViralCapsid ProteinsDNA PrimersRecombinant ProteinsRNA, ViralVP6 protein, Rotavirus

Identifiers

PMID9774561
PMCPMC105297
OpenAlexW2132237400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.