ArticleThe EMBO journal1998
Analysis of the functional specificity of RS domains in vivo.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Cellular sex throughout the organism underlies somatic sexual differentiation.Nature communications · 2024Article
- Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.RNA biology · 2013Article
- A role for the adult fat body in Drosophila male courtship behavior.PLoS genetics · 2007Article
- Concentration dependent selection of targets by an SR splicing regulator results in tissue-specific RNA processing.Nucleic acids research · 2006Article
- Arginine/serine repeats are sufficient to constitute a splicing activation domain.Nucleic acids research · 2003Article
- Nuclear export and retention signals in the RS domain of SR proteins.Molecular and cellular biology · 2002Article
- Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing.Nucleic acids research · 2001Article
- Role of SR protein modular domains in alternative splicing specificity in vivo.Nucleic acids research · 2000Article
- Sorting out the complexity of SR protein functions.RNA (New York, N.Y.) · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A number of splicing factors contain extensive regions that are rich in arginine and serine (RS domains). These domains are thought to facilitate protein-protein interactions that are critical in the regulation of alternative splicing. Using a domain swap strategy, we have tested the ability of RS domains from several proteins to substitute in vivo for an essential RS domain in the Drosophila splicing regulator TRA-2. By several criteria, RS domains were found to vary significantly in their ability to support the splicing regulation functions of TRA-2. The RS domain of dU2AF50 functioned efficiently, while that of the dSRp55 protein did not. Moreover, we find similar differences in the ability of RS domains to direct fusion proteins to discrete subnuclear sites at which TRA-2 associates with spermatocyte chromosomes. These results indicate that RS domains are not all functionally equivalent in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.