ArticleThe EMBO journal1998
c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 143 citations in OpenAlex.
- Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor.Immunologic research · 2016Article
- c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.The Journal of cell biology · 2011Article
- Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.PloS one · 2010Article
- Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.Endocrine reviews · 2009Review
- Two pathways of costimulation through CD28.Immunologic research · 2009Review
- Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells.Journal of lipid research · 2009Article
- Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence.Biological chemistry · 2008Review
- BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.Molecular and cellular biology · 2006Article
- Antagonistic functions of tetradecanoyl phorbol acetate-inducible-sequence 11b and HuR in the hormonal regulation of vascular endothelial growth factor messenger ribonucleic acid stability by adrenocorticotropin.Molecular endocrinology (Baltimore, Md.) · 2006Article
- JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells.Experimental eye research · 2006Article
- Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.The Journal of biological chemistry · 2005Article
- Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.Molecular and cellular biology · 2005Article
- Regulatory role of the 3' untranslated region (3'UTR) of rat 5' deiodinase (D1). effects on messenger RNA translation and stability.Endocrine · 2005Article
- Article
- The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.The EMBO journal · 2004Article
- Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome-bound substrate mRNA.The Journal of biological chemistry · 2004Article
- Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR.Molecular and cellular biology · 2004Article
- The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element-containing mRNA levels in virally transformed T cells.Molecular and cellular biology · 2004Article
- MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.The EMBO journal · 2004Article
- A GFP-based assay for rapid screening of compounds affecting ARE-dependent mRNA turnover.Nucleic acids research · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas signalling pathways involved in transcriptional control have been studied extensively, the pathways regulating mRNA turnover remain poorly understood. We are interested in the role of mRNA stability in cell activation and oncogenesis using PB-3c mast cells as a model system. In these cells the short-lived interleukin-3 (IL-3) mRNA is stabilized by ionomycin treatment and following oncogenesis. To identify the signalling pathways involved in these mechanisms, we analysed the effect of different kinase inhibitors. SB202190 and wortmannin were shown to antagonize ionomycin-induced IL-3 mRNA stabilization in PB-3c cells in the presence of actinomycin D, and this effect coincided with their ability to inhibit c-jun N-terminal kinase (JNK) activation by ionomycin. Moreover, transfection of activated MEKK1 amplified ionomycin-induced IL-3 mRNA expression at the post-transcriptional level, and a dominant-negative mutant of JNK counteracted mRNA stabilization by ionomycin. Taken together, these data indicate that JNK is involved in the regulation of IL-3 mRNA turnover in mast cells. In addition, transfection experiments revealed that the cis-acting AU-rich element in the 3' untranslated region of IL-3 mRNA is necessary and sufficient to confer JNK-dependent mRNA stabilization in response to cell activation.
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