ArticleThe EMBO journal1998
Chromatin interaction mechanism of transcriptional control in vivo.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Erythroid Cell Research: 3D Chromatin, Transcription Factors and Beyond.International journal of molecular sciences · 2022Review
- Monitoring the spatio-temporal organization and dynamics of the genome.Nucleic acids research · 2020Review
- Fetal γ-globin genes are regulated by theBlood · 2018Article
- Real-Time Imaging of a Single Gene Reveals Transcription-Initiated Local Confinement.Biophysical journal · 2017Article
- Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.Molecular cell · 2016Article
- Biased allelic expression in human primary fibroblast single cells.American journal of human genetics · 2015Article
- Quantitative analysis of genomic element interactions by molecular colony technique.Nucleic acids research · 2014Article
- Epigenetic modifications and chromosome conformations of the beta globin locus throughout development.Stem cell reviews and reports · 2013Article
- Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub.Nucleic acids research · 2013Article
- In vivo live imaging of RNA polymerase II transcription factories in primary cells.Genes & development · 2013Article
- Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation.Nature methods · 2013Article
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- Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.Nucleic acids research · 2011Article
- TMEM8 - a non-globin gene entrapped in the globin web.Nucleic acids research · 2009Article
- Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.Cell · 2008Article
- Spatial configuration of the chicken alpha-globin gene domain: immature and active chromatin hubs.Nucleic acids research · 2008Article
- 5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.PloS one · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used a kinetic analysis to distinguish possible mechanisms of activation of transcription of the different genes in the human beta globin locus. Based on in situ studies at the single-cell level we have previously suggested a dynamic mechanism of single genes alternately interacting with the locus control region (LCR) to activate transcription. However, those steady-state experiments did not allow a direct measurement of the dynamics of the mechanism and the presence of loci with in situ primary transcript signals from two beta-like genes in cis has left open the possibility that multiple genes in the locus could initiate transcription simultaneously. Kinetic assays involving removal of a block to transcription elongation in conjunction with RNA FISH show that multiple beta gene primary transcript signals in cis represent a transition between alternating transcriptional periods of single genes, supporting a dynamic interaction mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.