Evidence map›Paper›PMID 9771763›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry1998

Dystonia and chorea in acquired systemic disorders.

J L Janavs, M J Aminoff

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04083586 (Pattern and Frequency of Non-epileptic Involuntary Movements. Hospital-based Study), which is not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04083586 completednot on this mapstarted 2020, after this paper: background citation

Pattern and Frequency of Non-epileptic Involuntary Movements. Hospital-based Study

TypeobservationalSponsorAssiut UniversityRan2020 to 2021Enrolled144ConditionsInvoluntary MovementsArmsAll investigations, laboratory and radiological, needed for diagnosis
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dancing Out of Step: A Case of Tuberculous Meningitis Presenting as Childhood Chorea.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Late-Onset Chorea inMovement disorders clinical practice · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
  19. Article
  20. Chorea disclosing a polycythemia vera.Neuropsychiatric disease and treatment · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J L JanavsSchool of Medicine, University of California, San Francisco 94143, USA.
M J Aminoff
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dystonia and chorea are uncommon accompaniments, but sometimes the presenting features of certain acquired systemic disorders that presumably alter basal ganglia function. Hypoxia-ischaemia may injure the basal ganglia through hypoperfusion of subcortical vascular watershed regions and by altering striatal neurotransmitter systems. Toxins interfere with striatal mitochondrial function, resulting in cellular hypoxia. Infections may affect the basal ganglia by causing vasculitic ischaemia, through the development of antibodies to basal ganglia epitopes, by direct invasion of the basal ganglia by the organism, or through cytotoxins causing neuronal injury. Autoimmune disorders alter striatal function by causing a vasculopathy, by direct reaction of antibodies with basal ganglia epitopes, or by stimulating the generation of a cytotoxic or inflammatory reaction. Endocrine and electrolyte abnormalities influence neurotransmitter balance or affect ion channel function and signalling in the basal ganglia. In general, the production of chorea involves dysfunction of the indirect pathway from the caudate and putamen to the internal globus pallidus, whereas dystonia is generated by dysfunction of the direct pathway. The time of the onset of the movement disorder relative to the primary disease process, and course vary with the age of the patient and the underlying pathology. Treatment of dystonia or chorea associated with a systemic medical disorder must initially consider the systemic disorder.

Indexed as

AdolescentAdultBacterial InfectionsBrain IschemiaChildChoreaDystoniaHumansHypoxiaLupus Erythematosus, SystemicMiddle AgedToxemia

Identifiers

PMID9771763
PMCPMC2170280
OpenAlexW2167293566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.