ArticleNature medicine1998
Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge.
Article in Nature medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
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- Making vaccines "on demand": a potential solution for emerging pathogens and biodefense?Human vaccines & immunotherapeutics · 2013Review
- Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade.Veterinary research · 2011Article
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- How does HTLV-I persist despite a strong cell-mediated immune response?Trends in immunology · 2008Article
- Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.Retrovirology · 2007Review
- Dissemination of bovine leukemia virus-infected cells from a newly infected sheep lymph node.Journal of virology · 2006Article
- Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice.Journal of virology · 2006Article
- Adoptive immunotherapy of feline immunodeficiency virus with autologous ex vivo-stimulated lymphoid cells modulates virus and T-cell subsets in blood.Clinical and diagnostic laboratory immunology · 2005Article
- Antibodies, viruses and vaccines.Nature reviews. Immunology · 2002Review
- Longitudinal analysis of feline leukemia virus-specific cytotoxic T lymphocytes: correlation with recovery from infection.Journal of virology · 2002Article
- gammadelta(+) T-Lp6phocyte cytotoxicity against envelope-expressing target cells is unique to the alymphocytic state of bovine leukemia virus infection in the natural host.Journal of virology · 2000Article
- Kinetics of the development of protective immunity in mice vaccinated with a live attenuated retrovirus.Journal of virology · 1999Article
- Bovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model.Journal of virology · 1999Article
- Immunogenicity of a human immunodeficiency virus (HIV) polytope vaccine containing multiple HLA A2 HIV CD8(+) cytotoxic T-cell epitopes.Journal of virology · 1999Article
- Protection against establishment of retroviral persistence by vaccination with a live attenuated virus.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic T-lymphocyte (CTL), CD4-lymphocyteS, chemokine and/or antibody responses have all been associated with protection against HIV and AIDS; however, effective and safe vaccination strategies remain elusive. Here we show that vaccination with a minimal ovine CTL peptide epitope identified within gp51 of the retrovirus bovine leukemia virus (BLV), consistently induced peptide-specific CTLs. Only sheep whose CTLs were also capable of recognizing retrovirus-infected cells were fully protected when challenged with BLV. This retrovirus displays limited sequence variation; thus, in the relative absence of confounding CTL escape variants, virus-specific CTLs targeting a single epitope were able to prevent the establishment of a latent retroviral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.