ArticleGut1998
Reduced susceptibility of mice overexpressing transforming growth factor alpha to dextran sodium sulphate induced colitis.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Epidermal Growth Factor Attenuated the Expression of Inflammatory Cytokines in Human Epidermal Keratinocyte Exposed toAnnals of dermatology · 2018Article
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- Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation.EBioMedicine · 2016Article
- EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- ErbB receptors and their growth factor ligands in pediatric intestinal inflammation.Pediatric research · 2014Review
- Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium.Journal of inflammation research · 2013Article
- Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6.Journal of inflammation research · 2013Article
- Interferon-γ alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport.The Journal of biological chemistry · 2012Article
- Local delivery of growth factors using coated suture material.TheScientificWorldJournal · 2012Article
- Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.The Journal of clinical investigation · 2011Article
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.The Journal of experimental medicine · 2010Article
- Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.International journal of colorectal disease · 2010Article
- Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications.International wound journal · 2009Review
- ERBBs in the gastrointestinal tract: recent progress and new perspectives.Experimental cell research · 2009Review
- TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis.The Journal of clinical investigation · 2006Article
- Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage.Molecular and cellular biology · 2004Article
- Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor.British journal of pharmacology · 2002Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransforming growth factor alpha (TGF-alpha) knockout mice have increased susceptibility to dextran sodium sulphate (DSS) induced colitis.
aimTo substantiate the findings that TGF-alpha is a key mediator of colonic mucosal protection and/or repair mechanisms by evaluating the susceptibility of mice overexpressing TGF-alpha to DSS induced colitis.
methodsTGF-alpha overexpression was induced in transgenic mice by ZnSO4 administration in drinking water (TG+). Three groups were used as controls: one transgenic group without ZnSO4 administration (TG-), and two non-transgenic littermate groups receiving ZnSO4 (Non-TG+) or only water (Non-TG-). Acute colitis was induced in all groups by administration of DSS (5%, w/v) in drinking water for six days and libitum.
resultsAbout 35-39% of the entire colonic mucosa was destroyed in Non-TG-, Non-TG+, and TG- animals compared with 9% in TG+ mice. the crypt damage score was 18.7 (0.9), 18.2 (1.0), 18.9 (0.8), and 6.8 (1.5) (means (SEM)) in Non-TG-, Non-TG+, TG-, and TG+ mice respectively. Mucin and bromodeoxyuridine staining were markedly enhanced in colons of TG+ mice compared with controls, indicating increased mucosal protection and regeneration.
conclusionsThe significantly reduced susceptibility of mice overexpressing TGF-alpha to DSS further substantiates that endogenous TGF-alpha is a pivotal mediator of protection and/or healing mechanisms in the colon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.