ReviewJournal of molecular neuroscience : MN1998
Advances in the molecular characterization of tryptophan hydroxylase.
Review in Journal of molecular neuroscience : MN, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 95 citations in OpenAlex.
- SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Molecular psychiatry · 2004Trial
- The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity.Biochemistry and biophysics reports · 2023Article
- Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Protective Role of Melatonin and Its Metabolites in Skin Aging.International journal of molecular sciences · 2022Review
- Detection of Serotonin, Melatonin, and Their Metabolites in Honey.ACS food science & technology · 2021Article
- Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication.International journal of molecular sciences · 2021Review
- Microscopic Interactions of Melatonin, Serotonin and Tryptophan with Zwitterionic Phospholipid Membranes.International journal of molecular sciences · 2021Article
- Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells.Journal of pineal research · 2020Article
- A Comparative Genomics Study on the Molecular Evolution of Serotonin/Melatonin Biosynthesizing Enzymes in Vertebrates.Frontiers in molecular biosciences · 2020Review
- Feather follicles transcriptome profiles in Bashang long-tailed chickens with different plumage colors.Genes & genomics · 2019Article
- Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey.Genes · 2019Article
- Ankle edema after administration of selective serotonin reuptake inhibitors.Mental illness · 2018Article
- A Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation.Journal of the American Chemical Society · 2017Article
- Local melatoninergic system as the protector of skin integrity.International journal of molecular sciences · 2014Review
- Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei.Alcoholism, clinical and experimental research · 2014Article
- Boosting serotonin in the brain: is it time to revamp the treatment of depression?Journal of psychopharmacology (Oxford, England) · 2012Article
- Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Advances in anatomy, embryology, and cell biology · 2012Review
- Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior?Journal of proteome research · 2011Review
- Sekiguchi lesion gene encodes a cytochrome P450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice.The Journal of biological chemistry · 2010Article
- Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The neurotransmitter serotonin has been implicated in numerous physiological functions and pathophysiological disorders. The hydroxylation of the aromatic amino acid tryptophan is rate-limiting in the synthesis of serotonin. Tryptophan hydroxylase (TPH), as the rate-limiting enzyme, determines the concentrations of serotonin in vivo. Relative serotonin concentrations are clearly important in neural transmission, but serotonin has also been reported to function as a local antioxidant. Identification of the mechanisms regulating TPH activity has been hindered by its low levels in tissues and the instability of the enzyme. Several TPH expression systems have been developed to circumvent these problems. In addition, eukaryotic expressions systems are currently being developed and represent a new avenue of research for identifying TPH regulatory mechanisms. Recombinant DNA technology has enabled the synthesis of TPH deletions, chimeras, and point mutations that have served as tools for identifying structural and functional domains within TPH. Notably, the experiments have proven long-held hypotheses that TPH is organized into N-terminal regulatory and C-terminal catalytic domains, that serine-58 is a site for PKA-mediated phosphorylation, and that a C-terminal leucine zipper is involved in formation of the tetrameric holoenzyme. Several new findings have also emerged regarding regulation of TPH activity by posttranslational phosphorylation, kinetic inhibition, and covalent modification. Inhibition of TPH by L-DOPA may have implications for depression in Parkinson's disease (PD) patients. In addition, TPH inactivation by nitric oxide may be involved in amphetamine-induced toxicity. These regulatory concepts, in conjunction with new systems for studying TPH activity, are the focus of this article.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.