ArticleProceedings of the National Academy of Sciences of the United States of America1998
Free recombination within Helicobacter pylori.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers.
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Who cites it
275 citing papers in PubMed.
- Review
- Molecular Characterization and Genetic Diversity ofDiagnostics (Basel, Switzerland) · 2026Article
- Unveiling a missing component of the atypical type IV secretion system required for natural transformation of Helicobacter pylori.PLoS pathogens · 2026Article
- Genomic characterization of clinical Helicobacter pylori strains from Korea: insights into phylogeny, pan-genome structure, and virulence factors.BMC microbiology · 2026Article
- Unveiling a missing component of the atypical type IV secretion system required for natural transformation ofbioRxiv : the preprint server for biology · 2026Article
- Within-host diversity and phased variant analysis reveal structures and recombination of Helicobacter pylori subpopulations in stomach.GigaScience · 2026Article
- Genome-wide accumulations of non-random adaptive point mutations drive westward evolution of Helicobacter pylori.BMC microbiology · 2025Article
- Crystal structure of dihydroorotate dehydrogenase from Helicobacter pylori with bound flavin mononucleotide.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics.Microorganisms · 2025Article
- Molecular insights into the fine-tuning of pH-dependent ArsR-mediated regulation of the SabA adhesin in Helicobacter pylori.Nucleic acids research · 2024Article
- Review
- Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development.Cancer metastasis reviews · 2023Review
- High-Salt Diet ExacerbatesJournal of personalized medicine · 2023Review
- Advantages of Whole Genome Sequencing in Mitigating theMicroorganisms · 2023Article
- Helicobacter pylori infection.Nature reviews. Disease primers · 2023Review
- Mutations Related to Antibiotics Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- High prevalence ofFrontiers in microbiology · 2023Article
- Pathogenomics of Helicobacter pylori.Current topics in microbiology and immunology · 2023Review
- Application of biomaterials in the eradication ofFrontiers in microbiology · 2023Review
- Article
215 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage equilibrium by using the Homoplasy Test and compatibility matrices. Horizontal genetic exchange in H. pylori is so frequent that different loci and polymorphisms within each locus are all at linkage equilibrium. These results indicate that H. pylori is panmictic. Comparisons with sequences from Escherichia coli, Neisseria meningitidis, and Drosophila melanogaster showed that recombination in H. pylori was much more frequent than in other species. In contrast, when multiple family members infected with H. pylori were investigated, some strains were indistinguishable at all three loci. Thus, H. pylori is clonal over short time periods after natural transmission.
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