ArticleProceedings of the National Academy of Sciences of the United States of America1998
Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 166 citations in OpenAlex.
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- Food for thought: Nutrient metabolism controlling early T cell development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024Review
- RORγt up-regulates RAG gene expression in DP thymocytes to expand theScience immunology · 2024Article
- Contribution of αβ T cells to macrophage polarization and MSC recruitment and proliferation on titanium implants.Acta biomaterialia · 2023Article
- Multilingual translation for zero-shot biomedical classification using BioTranslator.Nature communications · 2023Article
- Direct regulation of TCR rearrangement and expression by E proteins during early T cell development.WIREs mechanisms of disease · 2022Review
- Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.The Journal of experimental medicine · 2022Article
- The E-Id Axis Instructs Adaptive Versus Innate Lineage Cell Fate Choice and Instructs Regulatory T Cell Differentiation.Frontiers in immunology · 2022Review
- Immune Gene Rearrangements: Unique Signatures for Tracing Physiological Lymphocytes and Leukemic Cells.Genes · 2021Review
- The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation ofFrontiers in immunology · 2021Review
- Tfh Cells in Health and Immunity: Potential Targets for Systems Biology Approaches to Vaccination.International journal of molecular sciences · 2020Review
- The development of human immune system mice and their use to study tolerance and autoimmunity.Journal of translational autoimmunity · 2019Review
- Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors.The Journal of experimental medicine · 2019Article
- The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.The Journal of experimental medicine · 2019Article
- The development of T cells from stem cells in mice and humans.Future science OA · 2017Review
- Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.The Journal of experimental medicine · 2016Article
- Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs.BMC infectious diseases · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a comprehensive analysis of T cell receptor (TCR) gamma rearrangements in T cell precursors of the mouse adult thymus. Using a sensitive quantitative PCR method, we show that TCRgamma rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes much earlier than expected. TCRgamma rearrangements increase significantly from the Pro-T to the CD44(-)CD25(+) Pre-T cell transition, and follow different patterns depending on each Vgamma gene segment, suggesting that ordered waves of TCRgamma rearrangement exist in the adult mouse thymus as has been described in the fetal mouse thymus. Recombinations of TCRgamma genes occur concurrently with TCRdelta and D-Jbeta rearrangements, but before Vbeta gene assembly. Productive TCRgamma rearrangements do not increase significantly before the Pre-T cell stage and are depleted in CD4(+)CD8(+) double-positive cells from normal mice. In contrast, double-positive thymocytes from TCRdelta-/- mice display random proportions of TCRgamma rearranged alleles, supporting a role for functional TCRgamma/delta rearrangements in the gammadelta divergence process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.