ArticleProceedings of the National Academy of Sciences of the United States of America1998
Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Association between Functional MICA-TM and Behcet's Disease: A Systematic Review and Meta-analysis.Scientific reports · 2016Pooled it
- Long term disease-free survival in acute leukemia patients recovering with increased gammadelta T cells after partially mismatched related donor bone marrow transplantation.Bone marrow transplantation · 2007Trial
- Targeting the MICA/B-NKG2D axis in cancer: from molecular structure to immunotherapeutic strategies-a narrative review.Translational cancer research · 2026Review
- What rheumatologists need to know about innate lymphocytes.Nature reviews. Rheumatology · 2016Review
- Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.PLoS pathogens · 2016Article
- Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Autoimmunity reviews · 2016Review
- High diversity of MIC genes in non-human primates.Immunogenetics · 2014Article
- New prospects on the NKG2D/NKG2DL system for oncology.Oncoimmunology · 2013Review
- The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind's future?Retrovirology · 2013Review
- Diversity of γδ T-cell antigens.Cellular & molecular immunology · 2013Review
- Immunogenetics of the NKG2D ligand gene family.Immunogenetics · 2012Review
- γδ T cell receptor ligands and modes of antigen recognition.Archivum immunologiae et therapiae experimentalis · 2011Review
- Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.Cancer immunology, immunotherapy : CII · 2009Article
- High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3.Genes and immunity · 2008Article
- The NKG2D receptor: immunobiology and clinical implications.Immunologic research · 2008Review
- Genotyping and segregation analyses indicate the presence of only two functional MIC genes in rhesus macaques.Immunogenetics · 2007Article
- Characterization of the gammadelta T cell response to acute leukemia.Cancer immunology, immunotherapy : CII · 2006Article
- Mucosal T lymphocytes--peacekeepers and warriors.Springer seminars in immunopathology · 2005Review
- Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer.The Journal of clinical investigation · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Distant relatives of major histocompatibility complex (MHC) class I molecules, human MICA and MICB, function as stress-induced antigens that are broadly recognized by intestinal epithelial gamma delta T cells. They may thus play a central role in the immune surveillance of damaged, infected, or otherwise stressed intestinal epithelial cells. However, the generality of this system in evolution and the mode of recognition of MICA and MICB are undefined. Analysis of cDNA sequences from various primate species defined translation products that are homologous to MICA and MICB. All of the MIC polypeptides have common characteristics, although they are extraordinarily diverse. The most notable alterations are several deletions and frequent amino acid substitutions in the putative alpha-helical regions of the alpha1 alpha2 domains. However, the primate MIC molecules were expressed on the surfaces of normal and transfected cells. Moreover, despite their sharing of relatively few identical amino acids in potentially accessible regions of their alpha1 alpha2 domains, they were recognized by diverse human intestinal epithelial gamma delta T cells that are restricted by MICA and MICB. Thus, MIC molecules represent a family of MHC proteins that are structurally diverse yet appear to be functionally conserved. The promiscuous mode of gamma delta T cell recognition of these antigens may be explained by their sharing of a single conserved interaction site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.