ArticleThe Journal of physiology1998
Facilitation of the presynaptic calcium current at an auditory synapse in rat brainstem.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 185 citations in OpenAlex.
- Presynaptic CaCell reports · 2026Article
- Presynaptic CabioRxiv : the preprint server for biology · 2026Article
- Inactivation of CaV1 and CaV2 channels.The Journal of general physiology · 2025Review
- Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process.The Journal of general physiology · 2024Article
- A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Influence of T-Bar on Calcium Concentration Impacting Release Probability.Frontiers in computational neuroscience · 2022Article
- Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons.Frontiers in cellular neuroscience · 2022Article
- Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex.Frontiers in synaptic neuroscience · 2021Article
- Diverse roles of Synaptotagmin-7 in regulating vesicle fusion.Current opinion in neurobiology · 2020Review
- Evidence of Biorealistic Synaptic Behavior in Diffusive Li-based Two-terminal Resistive Switching Devices.Scientific reports · 2020Article
- The Role of CaCell reports · 2019Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Diffusion of CaBiophysical journal · 2018Article
- Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Molecular moieties masking CaThe Journal of general physiology · 2018Article
- NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups.Open biology · 2017Article
- Dynamics of volume-averaged intracellular CaThe Journal of physiology · 2017Article
- Review
- The calyx of Held in the auditory system: Structure, function, and development.Hearing research · 2016Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
1. The presynaptic calcium current (IpCa) was recorded from the calyx of Held in rat brainstem slices using the whole-cell patch clamp technique. 2. Tetanic activation of IpCa by 1 ms depolarizing voltage steps markedly enhanced the amplitude of IpCa. Using a paired pulse protocol, the second (test) response was facilitated with inter-pulse intervals of less than 100 ms. The facilitation was greater at shorter intervals and was maximal (about 20%) at intervals of 5-10 ms. 3. When the test pulse duration was extended, the facilitation was revealed as an increased rate of IpCa activation. From the current-voltage relationship measured at 1 ms from onset, facilitation could be described by a shift in the half-activation voltage of about -4 mV. 4. IpCa facilitation was not attenuated when guanosine-5'-O-(3-thiotriphosphate) (GTPgammaS) or guanosine-5'-O-(2-thiodiphosphate) (GDPbetaS) was included in the patch pipette, suggesting that G-proteins are not involved in this phenomenon. 5. On reducing [Ca2+]o, the magnitude of facilitation diminished proportionally to the amplitude of IpCa. Replacement of [Ca2+]o by Ba2+ or Na+, or buffering of [Ca2+]i with EGTA or BAPTA attenuated IpCa facilitation. 6. We conclude that repetitive presynaptic activity can facilitate the presynaptic Ca2+ current through a Ca2+-dependent mechanism. This mechanism would be complementary to the action of residual Ca2+ on the exocytotic machinery in producing activity-dependent facilitation of synaptic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.